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The subclassification of papillary renal cell carcinoma does not affect oncological outcomes after nephron sparing surgery

World Journal of Urology volume 34, pages 347–352 (2016)Cite this article

Abstract

Objectives

To evaluate the oncological outcomes of papillary renal cell carcinoma (pRCC) following nephron sparing surgery (NSS) and to determine whether the subclassification type of pRCC could be a prognostic factor for recurrence, progression, and specific death.

Materials and methods

An international multicentre retrospective study involving 19 institutions and the French network for research on kidney cancer was conducted after IRB approval. We analyzed data of all patients with pRCC who were treated by NSS between 2004 and 2014.

Results

We included 486 patients. Tumors were type 1 pRCC in 369 (76 %) cases and type 2 pRCC in 117 (24 %) cases. After a mean follow-up of 35 (1–120) months, 8 (1.6 %) patients experienced a local recurrence, 12 (1.5 %) had a metastatic progression, 24 (4.9 %) died, and 7 (1.4 %) died from cancer. Patients with type I pRCC had more grade II (66.3 vs. 46.1 %; p < 0.001) and less grade III (20 vs. 41 %; p < 0.001) tumors. Three-year estimated cancer-free survival (CFS) rate for type 1 pRCC was 96.5 % and for type 2 pRCC was 95.1 % (p = 0.894), respectively. Three-year estimated cancer-specific survival rate for type 1 pRCC was 98.4 % and for type 2 pRCC was 97.3 % (p = 0.947), respectively. Tumor stage superior to pT1 was the only prognostic factor for CFS (HR 3.5; p = 0.03).

Conclusion

Histological subtyping of pRCC has no impact on oncologic outcomes after nephron sparing surgery. In this selected population of pRCC tumors, we found that tumor stage is the only prognostic factor for cancer-free survival.

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Authors and Affiliations

  1. Cancerology Committee of the French Association of Urology (CCAFU), Paris, France

    Pierre Bigot, Jean-Christophe Bernhard, Jean Baptiste Beauval, François Xavier Nouhaud, Jérôme Rigaud, Christian Pfister, Jean François Hetet, Guillaume Ploussard, Morgan Roupret, Stéphane Larré, Philippe Sebe, Michel Soulié, Arnaud Méjean, Karim Bensalah & Jean-Jacques Patard

  2. French Network for Research on Kidney Cancer (UroCCR), Bordeaux, France

    Pierre Bigot, Jean-Christophe Bernhard, Grégory Verhoest, Vincent Flamand, Jean Baptiste Beauval, François Xavier Nouhaud, Christian Pfister, Aurélien Descazeaud, Michel Soulié, Arnaud Méjean, Karim Bensalah & Jean-Jacques Patard

  3. Department of Urology, CHU Angers, Angers University Hospital, 4 rue Larrey, 49333, Angers, France

    Pierre Bigot & Abdel Rahmène Azzouzi

  4. Department of Urology, Bordeaux University Hospital, Bordeaux, France

    Jean-Christophe Bernhard & Nam Son Vuong

  5. USC Institute of Urology, University of Southern California, Los Angeles, CA, USA

    Inderbir S. Gill & Toru Matsugasumi

  6. Department of Urology, Pontchaillou University Hospital, Rennes, France

    Grégory Verhoest & Karim Bensalah

  7. Department of Urology, Lille University Hospital, Lille, France

    Vincent Flamand & Boris Reix

  8. Department of Urology, University Hospital of Ankara, Ankara, Turkey

    Evren Suer & Ilker Gökce

  9. Department of Urology, Toulouse University Hospital, Toulouse, France

    Jean Baptiste Beauval, François Xavier Nouhaud, Christian Pfister & Michel Soulié

  10. Department of Urology, University Hospital of Kumamoto, Kumamoto, Japan

    Masatoshi Eto

  11. Department of Urology, University Hospital of Oslo, Oslo, Norway

    Eduard Baco

  12. Department of Urology, Nantes University Hospital, Nantes, France

    Yvonne Chowaniec & Jérôme Rigaud

  13. Department of Urology, Rouen University Hospital, Rouen, France

    Claire Lenormand

  14. Department of Urology, Clinique Jules Vernes, Nantes, France

    Jean François Hetet

  15. Department of Urology, Saint-Louis University Hospital, APHP, Paris, France

    Guillaume Ploussard

  16. Department of Urology, La Pitié Salpetrière, APHP, Paris, France

    Morgan Roupret & Priscilla Léon

  17. University Paris 6, Faculty of Medicine Pierre and Marie Curie, Paris, France

    Morgan Roupret

  18. Department of Urology, Reims University Hospital, Reims, France

    Adnan El Bakri & Stéphane Larré

  19. Department of Urology, Caen University Hospital, Caen, France

    Xavier Tillou & Arnaud Doerfler

  20. Department of Urology, Limoges University Hospital, Limoges, France

    Aurélien Descazeaud

  21. Department of Urology, Dijon University Hospital, Dijon, France

    Nicolas Koutlidis & Alexandre Schneider

  22. Department of Urology, Groupe hospitalier Diaconesses, Paris, France

    Philippe Sebe

  23. Department of Urology, Bicêtre University Hospital, Le Kremlin Bicêtre, France

    Alexandre Ingels & Jean-Jacques Patard

  24. Department of Urology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France

    Arnaud Méjean

Authors
  1. Pierre Bigot
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  2. Jean-Christophe Bernhard
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  3. Inderbir S. Gill
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  4. Nam Son Vuong
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  5. Grégory Verhoest
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  6. Vincent Flamand
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  7. Boris Reix
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  8. Evren Suer
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  9. Ilker Gökce
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  10. Jean Baptiste Beauval
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  11. François Xavier Nouhaud
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  12. Masatoshi Eto
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  13. Eduard Baco
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  14. Toru Matsugasumi
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  15. Yvonne Chowaniec
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  16. Jérôme Rigaud
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  17. Claire Lenormand
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  18. Christian Pfister
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  19. Jean François Hetet
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  20. Guillaume Ploussard
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  21. Morgan Roupret
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  22. Priscilla Léon
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  23. Adnan El Bakri
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  24. Stéphane Larré
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  25. Xavier Tillou
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  26. Arnaud Doerfler
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  27. Aurélien Descazeaud
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  28. Nicolas Koutlidis
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  29. Alexandre Schneider
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  30. Philippe Sebe
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  31. Alexandre Ingels
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  32. Abdel Rahmène Azzouzi
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  33. Michel Soulié
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  34. Arnaud Méjean
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  35. Karim Bensalah
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  36. Jean-Jacques Patard
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Consortia

the members of the Kidney Cancer group of the CCAFU

Corresponding author

Correspondence to Pierre Bigot.

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Ethical standard

This retrospective study was performed after approval from each institutional review board.

Conflict of interest

All other authors state that they have no conflicts of interest that are directly or indirectly related to the research.

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Bigot, P., Bernhard, JC., Gill, I.S. et al. The subclassification of papillary renal cell carcinoma does not affect oncological outcomes after nephron sparing surgery. World J Urol 34, 347–352 (2016). https://doi.org/10.1007/s00345-015-1634-0

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  • DOI: https://doi.org/10.1007/s00345-015-1634-0

Keywords

  • Nephron sparing surgery
  • Papillary renal cell carcinoma
  • Oncologic outcomes