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Evaluation of 3 T pelvic MRI imaging in prostate cancer patients receiving post-prostatectomy IMRT

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Abstract

Purpose

The purpose of the study was to evaluate the utility of a 3 T pelvic magnetic resonance imaging (MRI) in detecting a local recurrence in post-prostatectomy prostate cancer patients prior to receiving adjuvant or salvage intensity-modulated radiation therapy (IMRT).

Methods

Ninety prostate cancer patients status post-prostatectomy with rising prostate-specific antigen (PSA) had a 3 T pelvic MRI prior to IMRT. The following variables were analyzed for predicting positive findings on MRI: initial presenting and initial post-op PSA, PSA at the time of imaging, PSA velocity, surgical margins, Gleason score, pathological stage, pre-RT digital rectal examination, and type of surgical prostatectomy.

Results

The only significant variable predictive of a positive MRI was positive margins. Specifically, 15 of 46 (33 %) patients with positive margins had a positive MRI, while 5 of 44 (11 %) patients with negative margins had a positive MRI. In the MRI positive group, the location of the positive findings on MRI corresponded with the pathology report in 9 of 12 (75 %) cases.

Conclusion

Post-prostatectomy patients with pathologic positive margins are three times more likely to have positive findings on a 3 T MRI.

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Conflict of interest

There are no conflicts of interest associated with this manuscript by any of the authors.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA

    Vivek Verma

  2. Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, Campus Box 8224, St. Louis, MO, 63110-6311, USA

    Jeff M. Michalski, Yanle Hu, Wenjun Zhang, Laura Eschen, Sandra Fergus, Dan Mullen & Hiram A. Gay

  3. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA

    Ling Chen

  4. Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA

    Kathryn Robinson

  5. Department of Surgery, Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO, USA

    Seth Strope & Robert Grubb III

  6. Department of Molecular Biology, Princeton University, Princeton, NJ, USA

    Shivam Verma

Authors
  1. Vivek Verma
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  2. Ling Chen
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  3. Jeff M. Michalski
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  4. Yanle Hu
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  5. Wenjun Zhang
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  6. Kathryn Robinson
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  7. Shivam Verma
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  8. Laura Eschen
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  9. Sandra Fergus
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  10. Dan Mullen
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  11. Seth Strope
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  12. Robert Grubb III
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  13. Hiram A. Gay
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Corresponding author

Correspondence to Hiram A. Gay.

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Verma, V., Chen, L., Michalski, J.M. et al. Evaluation of 3 T pelvic MRI imaging in prostate cancer patients receiving post-prostatectomy IMRT. World J Urol 33, 69–75 (2015). https://doi.org/10.1007/s00345-014-1269-6

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  • DOI: https://doi.org/10.1007/s00345-014-1269-6

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