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Impact of preoperative immunonutrition on morbidity following cystectomy for bladder cancer: a case–control pilot study

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Abstract

Purpose

To compare postoperative complications in patients with or without preoperative immunonutrition before cystectomy.

Methods

A prospective, multicenter, pilot, case–control study was conducted during 6 months. Patients with 7-day preoperative immunonutrition were prospectively included and compared with a retrospective, matched control group without immunonutrition. Early complication rates and the length of hospital stay were analyzed. The bilateral type I error was <0.05; the power was 90 %. Thirty patients in each group were required.

Results

Thirty patients were included in each group, on a comparable basis. In the immunonutrition group, fewer postoperative complications (40 vs. 76.7 %; p = 0.008), less paralytic ileus at D7 (6.6 vs. 33.3 %; p = 0.02), fewer infections (23.3 vs. 60 %; p = 0.008), and in particular less pyelonephritis (16.7 vs. 46.7 %; p = 0.03) occurred. Clavien’s grades for complications were higher in the control group (p = 0.04). Mortality, pulmonary embolism, anastomotic fistulae, and wound dehiscence were similar between two groups. The length of stay was reduced by 3 days in the immunonutrition group.

Conclusions

In this pilot case–control study, immunonutrition is associated with a decrease in postoperative complications, urinary tract infections, Clavien’s grade for complications, and paralytic ileus in patients undergoing cystectomy for bladder cancer. Prospective randomized placebo control studies are needed to confirm these promising results.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Uro-Andrology, Carémeau University Hospital, Nîmes, France

    J. Bertrand, N. Siegler, P. Gres, L. Wagner, P. Costa & S. Droupy

  2. Department of Uro-Andrology, Lapeyronie University Hospital, Montpellier, France

    T. Murez, G. Poinas & R. Thuret

  3. Department of Uro-Andrology, Bassin de Thau Hospital, Sète, France

    B. Segui

  4. Department of Uro-Andrology, Clinique Mutualiste Beausoleil, Montpellier, France

    B. Segui & D. Ayuso

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  1. J. Bertrand
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  2. N. Siegler
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  3. T. Murez
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  4. G. Poinas
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  5. B. Segui
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  7. P. Gres
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  10. P. Costa
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Correspondence to J. Bertrand.

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Bertrand, J., Siegler, N., Murez, T. et al. Impact of preoperative immunonutrition on morbidity following cystectomy for bladder cancer: a case–control pilot study. World J Urol 32, 233–237 (2014). https://doi.org/10.1007/s00345-013-1229-6

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  • DOI: https://doi.org/10.1007/s00345-013-1229-6

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