Skip to main content

Advertisement

SpringerLink
Log in

Sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome

  • Topic Paper
  • Published:
World Journal of Urology Aims and scope Submit manuscript

Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), or NIH category III prostatitis, is a common clinical syndrome characterized by genital/pelvic pain and lower urinary tract symptoms in the absence of urinary tract infection. There is also growing recognition of the association of sexual dysfunction with CP/CPPS including erectile dysfunction, ejaculatory pain, and premature ejaculation. In this review, we discuss the association between CP/CPPS and sexual dysfunction, potential mechanisms for sexual dysfunction, and treatment strategies for erectile dysfunction in CP/CPPS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Schaeffer AJ, Datta NS, Fowler JE et al (2002) Overview summary statement. Urology 60(6):1–4

    Article  PubMed  Google Scholar 

  2. McNaughton Collins M, Pontari MA, O’Leary MP et al (2004) Quality of life is impaired in men with chronic prostatitis the chronic prostatitis collaborative research network. J Gen Intern Med 16(10):656–662

    Article  Google Scholar 

  3. Lee S, Liong ML, Yuen KH et al (2008) Adverse impact of sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome. Urology 71(1):79

    Article  PubMed  Google Scholar 

  4. Blanker MH, Bosch J, Groeneveld FPMJ et al (2001) Erectile and ejaculatory dysfunction in a community-based sample of men 50 to 78 years old: prevalence, concern, and relation to sexual activity. Urology 57(4):763–768

    Article  PubMed  CAS  Google Scholar 

  5. Shoskes DA, Landis JR, Wang Y, Nickel JC, Zeitlin SI, Nadler R (2004) Impact of post-ejaculatory pain in men with category III chronic prostatitis/chronic pelvic pain syndrome. J Urol 172(2):542–547

    Article  PubMed  Google Scholar 

  6. Litwin MS, McNaughton-Collins M, Fowler FJ et al (1999) The national institutes of health chronic prostatitis symptom index: development and validation of a new outcome measure. J Urol 162(2):369–375

    Article  PubMed  CAS  Google Scholar 

  7. Trinchieri A, Magri V, Cariani L et al (2007) Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome. Arch Ital Urol Androl 79(2):67

    PubMed  Google Scholar 

  8. Nickel JC, Elhilali M, Vallancien G (2005) Benign prostatic hyperplasia (BPH) and prostatitis: prevalence of painful ejaculation in men with clinical BPH. BJU Int 95(4):571–574

    Article  PubMed  Google Scholar 

  9. Krieger JN, Egan KJ, Ross SO, Jacobs R, Berger RE (1996) Chronic pelvic pains represent the most prominent urogenital symptoms of “chronic prostatitis”. Urology 48(5):715–722

    Article  PubMed  CAS  Google Scholar 

  10. Schultheiss D (2008) Urogenital infections and male sexuality: effects on ejaculation and erection. Andrologia 40(2):125–129

    Article  PubMed  CAS  Google Scholar 

  11. Shamloul R, Nashaar A (2005) Chronic prostatitis in premature ejaculation: a cohort study in 153 men. J Sex Med 3(1):150–154

    Article  Google Scholar 

  12. Screponi E, Carosa E, Di Stasi SM, Pepe M, Carruba G, Jannini EA (2001) Prevalence of chronic prostatitis in men with premature ejaculation. Urology 58(2):198–202

    Article  PubMed  CAS  Google Scholar 

  13. Liang CZ, Zhang XJ, Hao ZY, Shi HQ, Wang KX (2004) Prevalence of sexual dysfunction in Chinese men with chronic prostatitis. BJU Int 93(4):568–570

    Article  PubMed  Google Scholar 

  14. Gonen M, Kalkan M, Cenker A, Ozkardes H (2005) Prevalence of premature ejaculation in Turkish men with chronic pelvic pain syndrome. J Androl 26(5):601

    Article  PubMed  Google Scholar 

  15. Hao ZY, Li HJ, Wang ZP et al (2011) The prevalence of erectile dysfunction and its relation to chronic prostatitis in Chinese men. J Androl 32(5):496

    Article  PubMed  Google Scholar 

  16. Qiu Y, Xie C, Zeng X, Zhang J (2007) Investigation of sexual function in 623 patients with chronic prostatitis. Natl J Androl 13(6):524

    Google Scholar 

  17. Tan J, Pug D, Liew L, Li M, Wong M (2002) Prevalence of prostatitis-like symptoms in Singapore: a population-based study. Singap Med J 43(4):189–193

    CAS  Google Scholar 

  18. Chung SD, Keller JJ, Lin HC (2012) A case‐control study on the association between chronic prostatitis/chronic pelvic pain syndrome and erectile dysfunction. BJU Int 110:726

    Google Scholar 

  19. Shoskes DA (2012) The challenge of erectile dysfunction in the man with chronic Prostatitis/Chronic pelvic pain syndrome. Curr urol rep 13:263

    Google Scholar 

  20. Shoskes DA, Prots D, Karns J, Horhn J, Shoskes AC (2011) Greater endothelial dysfunction and arterial stiffness in men with chronic prostatitis/chronic pelvic pain syndrome—A possible link to cardiovascular disease. J Urol 186(3):907–910

    Article  PubMed  Google Scholar 

  21. Shoskes DA, Berger R, Elmi A, Landis JR, Propert KJ, Zeitlin S (2008) Muscle tenderness in men with chronic prostatitis/chronic pelvic pain syndrome: the chronic prostatitis cohort study. J Urol 179(2):556–560

    Article  PubMed  Google Scholar 

  22. Anderson RU, Wise D, Sawyer T, Chan CA (2006) Sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: improvement after trigger point release and paradoxical relaxation training. J Urol 176(4):1534–1537

    Article  PubMed  Google Scholar 

  23. Giammusso B, Gattuso U, Vanaclocha V et al (2005) Percutaneous lumbar sympathectomy in the treatment of erectile dysfunction secondary to cavernous adrenergic hypertone: initial results of an original technique. Arch Ital Urol Androl 77(1):5–9

    PubMed  Google Scholar 

  24. Ghanem H, Shamloul R (2007) An Evidence-Based perspective to commonly performed erectile dysfunction investigations. J Sex Med 5(7):1582–1589

    Article  Google Scholar 

  25. Pontari MA, Ruggieri MR (2004) Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol 172(3):839–845

    Article  PubMed  Google Scholar 

  26. Pontari MA, Ruggieri MR (2008) Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol 179(5):S61–S67

    Article  PubMed  Google Scholar 

  27. Dimitrakov J, Joffe HV, Soldin SJ, Bolus R, Buffington C, Nickel JC (2008) Adrenocortical hormone abnormalities in men with chronic prostatitis/chronic pelvic pain syndrome. Urology 71(2):261–266

    Article  PubMed  Google Scholar 

  28. Daniell HW (2002) Hypogonadism in men consuming sustained-action oral opioids. J Pain off J Am Pain Soc 3(5):377

    Article  Google Scholar 

  29. Dahiya R, Chui R, Perinchery G, Nakajima K, Oh BR, Lue TF (1999) Differential gene expression of growth factors in young and old rat penile tissues is associated with erectile dysfunction. Int J Impot Res 11(4):201–206

    Article  PubMed  CAS  Google Scholar 

  30. Aubin S, Berger R, Heiman J, Ciol M (2008) The association between sexual function, pain, and psychological adaptation of men diagnosed with chronic pelvic pain syndrome type III. J Sex Med 5(3):657

    Article  PubMed  Google Scholar 

  31. Mehik A, Hellström P, Sarpola A, Lukkarinen O, Järvelin MR (2001) Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int 88(1):35–38

    Article  PubMed  CAS  Google Scholar 

  32. Shoskes DA, Nickel JC, Kattan MW (2010) Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT. Urology 75(6):1249–1253

    Article  PubMed  Google Scholar 

  33. Shoskes D, Nickel J, Rackley R, Pontari M (2008) Clinical phenotyping in chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis: a management strategy for urologic chronic pelvic pain syndromes. Prostate Cancer Prostatic Dis 12(2):177–183

    Article  PubMed  Google Scholar 

  34. Hedelin HH (2009) Evaluation of a modification of the UPOINT clinical phenotype system for the chronic pelvic pain syndrome. Scand J Urol Nephrol 43(5):373–376

    Article  PubMed  Google Scholar 

  35. Magri V, Wagenlehner F, Perletti G et al (2010) Use of the UPOINT chronic prostatitis/chronic pelvic pain syndrome classification in european patient cohorts: sexual function domain improves correlations. J Urol 184(6):2339–2345

    Article  PubMed  Google Scholar 

  36. Samplaski MK, Li J, Shoskes DA (2011) Inclusion of erectile domain to UPOINT phenotype does not improve correlation with symptom severity in men with chronic prostatitis/chronic pelvic pain syndrome. Urology 78(3):653–658

    Article  PubMed  Google Scholar 

  37. Nickel JC, Elhilali M, Emberton M, Vallancien G (2006) The beneficial effect of alfuzosin 10 mg once daily in ‘real-life’practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation. BJU Int 97(6):1242–1246

    Article  PubMed  CAS  Google Scholar 

  38. Faydaci G, Kuyumcuoglu U, Eryildirim B, Aktas A, Tarhan F, Tuncer M (2011) Effectiveness of doxazosin on erectile dysfunction in patients with lower urinary tract symptoms. Int Urol Nephrol 43(3):619–624

    Article  PubMed  CAS  Google Scholar 

  39. Zhang W, Wang Y, Yang Z et al (2011) Antioxidant treatment with quercetin ameliorates erectile dysfunction in streptozotocin-induced diabetic rats. J Biosci Bioeng 112(3):215–218

    Article  PubMed  CAS  Google Scholar 

  40. Grimsley S, Khan M, Jones G (2007) Mechanism of phosphodiesterase 5 inhibitor relief of prostatitis symptoms. Med Hypotheses 69(1):25–26

    Article  PubMed  CAS  Google Scholar 

  41. Gacci M, Corona G, Salvi M, Vignozzi L, McVary KT, Kaplan SA, Roehrborn CG, Serni S, Mirone V, Carini M, Maggi M (2012) A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with alpha-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 61: 994

    Google Scholar 

  42. Eryildirim B, Aktas A, Kuyumcuoglu U, Faydaci G, Tarhan F, Ozgül A (2010) The effectiveness of sildenafil citrate in patients with erectile dysfunction and lower urinary system symptoms and the significance of asymptomatic inflammatory prostatitis. Int J Impotence Res 22(6):349–354

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Desk Q10-1, Cleveland, OH, 44195, USA

    Christine N. Tran & Daniel A. Shoskes

Authors
  1. Christine N. Tran
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniel A. Shoskes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel A. Shoskes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tran, C.N., Shoskes, D.A. Sexual dysfunction in chronic prostatitis/chronic pelvic pain syndrome. World J Urol 31, 741–746 (2013). https://doi.org/10.1007/s00345-013-1076-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00345-013-1076-5

Keywords

Search

Navigation