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Scrotal cancer survival is influenced by histology: a SEER study

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Abstract

Introduction

Due to the scrotum’s multiple layers of different tissues, scrotal cancer can present with several unique histologies. Historically, outcome arising from these different sources has been historically aggregated together. However, it remains unclear whether survival differs by histology of scrotal cancer.

Methods

We queried the seventeen registries of the Surveillance, Epidemiology, and End Results database for patients diagnosed with primary scrotal cancer from 1973 to 2006. Patients were initially grouped by the following histologies: basal cell carcinoma, Extramammary Paget’s Disease (EMPD), sarcoma, melanoma, squamous cell carcinoma, and adnexal skin tumors. For some analyses, the former three histologies were reclassified as Low-Risk scrotal cancer and the latter three histologies as High-Risk scrotal cancer. Kaplan–Meier survival analyses were conducted to assess the impact of histology on overall survival (OS).

Results

The cohort consisted of 766 patients. Median (95% CI) OSs by histologies were basal cell carcinoma—143 (116–180), EMPD—165 (139–190), sarcoma—180 (141–219), melanoma—136 (70–203), squamous cell carcinoma—115 (97–133), and adnexal skin tumors—114 (55–174). Patients with Low-Risk scrotal cancer experienced a median (95% CI) OS of 166 (145–188) months, while patients with High-Risk scrotal cancer experienced a median (95% CI) OS of 118 (101–135) months.

Conclusions

Survival of scrotal cancer depends on tumor histology. Classification of histologies into Low and High Risk can be clinically useful for counseling and clinical decisions.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, Emory University, 1365 Clifton Road NE, Atlanta, GA, 30322, USA

    Timothy V. Johnson, Wayland Hsiao, Daniel J. Canter & Viraj A. Master

  2. Department of Surgery, Emory University, Atlanta, GA, USA

    Keith A. Delman

  3. Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Keith A. Delman & Viraj A. Master

Authors
  1. Timothy V. Johnson
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  2. Wayland Hsiao
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  3. Keith A. Delman
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  4. Daniel J. Canter
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  5. Viraj A. Master
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Corresponding author

Correspondence to Timothy V. Johnson.

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Johnson, T.V., Hsiao, W., Delman, K.A. et al. Scrotal cancer survival is influenced by histology: a SEER study. World J Urol 31, 585–590 (2013). https://doi.org/10.1007/s00345-012-0834-0

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  • DOI: https://doi.org/10.1007/s00345-012-0834-0

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