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The role of randomized controlled trials in evidence-based urology

World Journal of Urology volume 29, pages 257–263 (2011)Cite this article

Abstract

Purpose

To review the current and future role of randomized controlled trials (RCTs) in urology.

Methods

A review of the urological literature was performed to assess the current role of RCTs in urology. These findings were put in context of current practice, and methodologic limitations of observational study design were discussed.

Results

Several RCTs have improved treatment of urology patients. However, overall, few studies in the urologic literature convey high-level evidence. RCTs represent the only study design that can assess causality, thus are the only means to significantly advance knowledge about therapy and improve patient care. Increased incidence and improved quality of RCTs may be achieved through education, community outreach, and better access to research infrastructure.

Conclusions

RCTs have significantly improved urologic practice. RCTs are superior to observational studies because of decreased risk of bias and confounding. To further advance clinical practice, clinical trials must play a predominant role and should be embraced by the urology community.

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Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Affiliations

  1. Department of Surgery, Division of Urology, Ottawa University Hospital, General Campus, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada

    Luke T. Lavallée & Rodney H. Breau

  2. The Ottawa Health Research Institute, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada

    Dean Fergusson

Authors
  1. Luke T. Lavallée
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  2. Dean Fergusson
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  3. Rodney H. Breau
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Correspondence to Rodney H. Breau.

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Lavallée, L.T., Fergusson, D. & Breau, R.H. The role of randomized controlled trials in evidence-based urology. World J Urol 29, 257–263 (2011). https://doi.org/10.1007/s00345-011-0646-7

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  • DOI: https://doi.org/10.1007/s00345-011-0646-7

Keywords

  • Evidence-based medicine
  • Randomized controlled trial
  • Urology