Skip to main content

Advertisement

Log in

Testicular metastases: a poor prognostic factor in patients with advanced prostate cancer

  • Original Article
  • Published:
World Journal of Urology Aims and scope Submit manuscript

Abstract

Purpose

Prostate cancer is the most frequently diagnosed neoplasm in men. In some patients, however, the disease pursues a clearly more aggressive course. Testicular metastases from prostate cancer are rare events that have been previously reported; however, its frequency and clinical meaning are not well established. The aim of the present study was, therefore, to evaluate its occurrence and clinical meaning.

Patients and methods

A review of patients who underwent androgen deprivation orchidectomy for prostate cancer between 1995 and 2007 was undertaken. On the period evaluated, 1,693 orchidectomies were performed at our institution. Since, the population of patients treated at our institution does not have access to the expensive androgen-deprivation drugs, the vast majority is treated through surgical castration. In such context, evaluation of testicular parenchyma of patients with advanced prostate cancer could be assessed. Clinical and histological data were reviewed, and patients with testicular metastases were identified.

Results

Of the 1,693 orchidectomies performed during the period analysed, three cases of testicular metastases of prostate cancer (range 58–76 years) were diagnosed (0.18%). All patients had very atypical neoplasm’s behaviour and poor prognosis, dying within the first year.

Conclusion

In conclusion, testicular metastases from prostate cancer are a rare event, observed in 1.8 per 1,000 cases. As other visceral metastases, testicular metastases might also be considered as an unusual additional factor of poor prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Boyle P, Maisonneuve P, Napalkov P (1995) Geographical and temporal patterns of incidence and mortality from prostate cancer. Urology 46(3 Suppl A):47–55

    Article  PubMed  CAS  Google Scholar 

  2. Adolfsson J, Steineck G, Hedlund PO (1999) Deferred treatment of locally advanced nonmetastatic prostate cancer: a long-term followup. J Urol 161(2):505–508

    Article  PubMed  CAS  Google Scholar 

  3. Jesus CM, Goldberg J, Camargo JL (2005) Single testicular metastasis mimicking primary testicular neoplasm: a rare manifestation of prostate cancer. Int Braz J Urol 31(1):54–56

    Article  PubMed  Google Scholar 

  4. Tu SM, Reyes A, Maa A, Bhowmick D, Pisters LL, Pettaway CA et al (2002) Prostate carcinoma with testicular or penile metastases. Clinical, pathologic, and immunohistochemical features. Cancer 94(10):2610–2617

    Article  PubMed  Google Scholar 

  5. Benchekroun A, Kasmaoui EH, Ghadouane M, Jira H, Lachkar A, Marzouk M et al (2001) Testicular metastasis of prostatic adenocarcinoma. Report of a case. Ann Urol (Paris) 35(4):234–236

    CAS  Google Scholar 

  6. Dutt N, Bates AW, Baithun SI (2000) Secondary neoplasms of the male genital tract with different patterns of involvement in adults and children. Histopathology 37(4):323–331

    Article  PubMed  CAS  Google Scholar 

  7. Figg WD, Franks ME, Venzon D, Duray P, Cox MC, Linehan WM et al (2004) Gleason score and pretreatment prostate-specific antigen in survival among patients with stage D2 prostate cancer. World J Urol 22(6):425–430

    Article  PubMed  Google Scholar 

  8. Yossepowitch O, Bianco FJ Jr, Eggener SE, Eastham JA, Scher HI, Scardino PT (2007) The natural history of noncastrate metastatic prostate cancer after radical prostatectomy. Eur Urol 51(4):940–947 discussion 947–8

    Article  PubMed  Google Scholar 

Download references

Conflict of interest statement

There is no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fernando Korkes.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Korkes, F., Gasperini, R., Korkes, K.L. et al. Testicular metastases: a poor prognostic factor in patients with advanced prostate cancer. World J Urol 27, 113–115 (2009). https://doi.org/10.1007/s00345-008-0322-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00345-008-0322-8

Keywords

Navigation