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Association between atherosclerosis and urothelial tumors of the renal pelvis

World Journal of Urology volume 26, Article number: 375 (2008) Cite this article

Abstract

Objectives

An association between the prevalence of general and local atherosclerosis and various types of cancer has previously been reported. The present study therefore aimed to morphometrically compare atherosclerotic changes in kidneys with urothelial carcinomas of the renal pelvis and tumor-negative renal tissue.

Materials and methods

The intima-to-media ratio (IMR), which is the most sensitive marker for the degree of atherosclerosis, was evaluated in arteries (n = 492) of non-invasive papillary urothelial carcinoma (n = 128), invasive urothelial carcinoma (n = 168) and tumor-negative renal specimens (n = 196).

Results

IMR was significantly higher and more often exceeded 1 in invasive and non-invasive urothelial carcinomas than in tumor-negative specimens. Furthermore, in invasive urothelial carcinomas IMR was significantly higher in immediately peritumorous arteries than in more distant arteries. Moreover, IMR correlated weakly with age and renal parenchymal inflammation but not with peritumorous inflammation, coronary heart disease (CHD) or gender.

Conclusion

Local atherosclerosis was more pronounced in tumor-positive than in tumor-negative renal specimens. IMR > 1 was significantly associated with urothelial tumors and the overall odds of having a urothelial tumor were significantly greater for patients with an IMR > 1 than for patients with an IMR ≤ 1, supporting the view that patients with local atherosclerotic lesions are at elevated risk for urothelial carcinoma of the renal pelvis.

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References

  1. Cohen SM, Shirai T, Steineck G (2000) Epidemiology and etiology of premalignant and malignant urothelial changes. Scand J Urol Neprol Suppl (205):105–115

  2. Kirkali Z, Tuzel E (2003) Transitional cell carcinoma of the ureter and renal pelvis. Crit Rev Oncol Hematol 47:155–169

    PubMed  Article  Google Scholar 

  3. Jensen OM, Knudsen JB, McLaughlin JK, Sorensen BL (1988) The copenhagen case-control study of renal pelvis and ureter cancer: role of smoking and occupational exposures. Int J Cancer 41:557–561

    PubMed  Article  CAS  Google Scholar 

  4. Akcay T, Saygili I, Andican G, Yalcin V (2003) Increased formation of 8-hydroxy–2′-deoxyguanosine in peripheral blood leukocytes in bladder cancer. Urol Int 71:271–274

    PubMed  Article  CAS  Google Scholar 

  5. Palvio DH, Andersen JC, Falk E (1987) Transitional cell tumors of the renal pelvis and ureter associated with capillarosclerosis indicating analgesic abuse. Cancer 59:972–976

    PubMed  Article  CAS  Google Scholar 

  6. Dreyer L, Olsen JH (1999) Risk for non-smoking-related cancer in atherosclerotic patients. Cancer Epidemiol Biomarkers Prev 8:915–918

    PubMed  CAS  Google Scholar 

  7. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, Ginsburg GS (2001) Atherosclerosis and cancer: common molecular pathways of disease development and progression. Ann N Y Acad Sci 947:271–292

    PubMed  CAS  Google Scholar 

  8. Tegos TJ, Kalodiki E, Sabetai MM, Nicolaides AN (2001) The genesis of atherosclerosis and risk factors: a review. Angiology 52:89–98

    PubMed  Article  CAS  Google Scholar 

  9. Budin RE, McDonnell PJ (1984) Renal cell neoplasms. Their relationship to arteriolonephrosclerosis. Arch Pathol Lab Med 108:138–140

    PubMed  CAS  Google Scholar 

  10. Dreyer L, Prescott E, Gyntelberg F (2003) Association between atherosclerosis and female lung cancer–a Danish cohort study. Lung Cancer 42:247–254

    PubMed  Article  Google Scholar 

  11. Ganzen TN, Aliaev I, Iargin SV (1989) Background and precancerous processes in renal cell carcinoma. Arkh Patol 51:30–38

    PubMed  CAS  Google Scholar 

  12. Kogan EA, Ganzen TN, Serov VV (1992) Sclerosis and carcinogenesis. Arkh Patol 54:5–11

    PubMed  CAS  Google Scholar 

  13. Hager M, Mikuz G, Bartsch G, Kolbitsch C, Moser PL (2007) The association between local atherosclerosis and prostate cancer. BJU Int 99:46–48

    PubMed  Article  Google Scholar 

  14. Correa P, Strong JP, Johnson WD, Pizzolato P, Haenszel W (1982) Atherosclerosis and polyps of the colon. Quantification of precursors of coronary heart disease and colon cancer. J Chronic Dis 35:313–320

    PubMed  Article  CAS  Google Scholar 

  15. Stemmermann GN, Heilbrun LK, Nomura A, Yano K, Hayashi T (1986) Adenomatous polyps and atherosclerosis: an autopsy study of Japanese men in Hawaii. Int J Cancer 38:789–794

    PubMed  Article  CAS  Google Scholar 

  16. Loft S, Poulsen HE (1996) Cancer risk and oxidative DNA damage in man. J Mol Med 74:297–312

    PubMed  Article  CAS  Google Scholar 

  17. Paul SA, Simons JW, Mabjeesh NJ (2004) HIF at the crossroads between ischemia and carcinogenesis. J Celll Physiol 200:20–30

    Article  CAS  Google Scholar 

  18. Ferro M, Conti M, Novero D, Micca FB, Palestro G (1991) The thin intima of the internal mammary artery as the possible reason for freedom from atherosclerosis and success in coronary bypass. Am Heart J 122:1192–1195

    PubMed  Article  CAS  Google Scholar 

  19. Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W Jr, Richardson M, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD (1992) A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 85:391–405

    PubMed  CAS  Google Scholar 

  20. Aboyans V, Lacroix P, Criqui MH (2007) Large and small vessels atherosclerosis: similarities and differences. Prog Cardiovasc Dis 50:112–125

    PubMed  Article  Google Scholar 

  21. Chade AR, Lerman A, Lerman LO (2005) Kidney in early atherosclerosis. Hypertension 45:1042–1049

    PubMed  Article  CAS  Google Scholar 

  22. Jensen OM, Knudsen JB, Tomasson H, Sorensen BL (1989) The Copenhagen case-control study of renal pelvis and ureter cancer: role of analgesics. Int J Cancer 44:965–968

    PubMed  Article  CAS  Google Scholar 

  23. Ditscherlein G, Ditscherlein K, Becker K, Reinhold F, Marten U, Schill S, Schill H, Tessmann D, Mesewinkel F, Schmitt J (1991) Analgesic nephropathy (AN) with special reference to capillary sclerosis. A multicenter study from the former East Germany. Zentralbl Pathol 137:123–129

    PubMed  CAS  Google Scholar 

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Conflict of interest statement

There is no conflict of interest.

Author information

Affiliations

  1. Department of Pathology, Paracelsus Medical University (PMU), Salzburg, Müllner Hauptstrasse 48, 5020, Salzburg, Austria

    Martina Hager & Heike Haufe

  2. Department of Pathology, Innsbruck Medical University (MUI), Innsbruck, Austria

    Gregor Mikuz, Katharina B. Moser & Patrizia L. Moser

  3. Department of Anaesthesia and Intensive Care Medicine, Innsbruck Medical University (MUI), Innsbruck, Austria

    Christian Kolbitsch

Authors
  1. Martina Hager
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  2. Gregor Mikuz
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  3. Heike Haufe
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  4. Christian Kolbitsch
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  5. Katharina B. Moser
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  6. Patrizia L. Moser
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Correspondence to Martina Hager.

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Hager, M., Mikuz, G., Haufe, H. et al. Association between atherosclerosis and urothelial tumors of the renal pelvis. World J Urol 26, 375 (2008). https://doi.org/10.1007/s00345-008-0271-2

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  • DOI: https://doi.org/10.1007/s00345-008-0271-2

Keywords

  • Atherosclerosis
  • Urothelial carcinoma
  • Intima-to-media ratio
  • Renal pelvis