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A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men

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Abstract

Objectives

To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD).

Methods

We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 core biopsy and 468 sextant biopsy of the prostate. The cancer detection rates achieved by these two methods were analyzed at different PSAD levels.

Results

All patients were stratified into 5 groups according to PSAD level; group A: PSAD < 0.1 (n = 290), group B: 0.1 ≤ PSAD < 0.2 (n = 572), group C: 0.2 ≤ PSAD < 0.3 (n = 248), group D: 0.3 ≤ PSAD < 0.4 (n = 122), and group E: PSAD ≥ 0.4 (n = 231). In group B, 12 core biopsy had a higher detection rate than 6 core biopsy (P = 0.017).

Conclusions

These results demonstrate 12 core biopsy is better able to detect cancer than 6 core biopsy in patients with a PSAD in the range 0.1–0.2, which suggests that PSAD be considered when deciding on the number of prostate biopsy cores required.

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Conflict of interest statement

There is no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, Seoul National University Hospital, 28 Yeongeon-dong, Chongro-gu, Seoul, 110-744, Korea

    Cheol Kwak, Eunsik Lee & Tae Beom Kim

  2. Department of Urology, Seoul Municipal Boramae Hospital, Seoul, Korea

    Hyeon Jeong & Byong Chang Jeong

  3. Department of Urology, Seoul National University Bundang Hospital, Seoul, Korea

    Sang Eun Lee

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  1. Hyeon Jeong
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  2. Byong Chang Jeong
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  3. Cheol Kwak
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  4. Eunsik Lee
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Correspondence to Tae Beom Kim.

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Jeong, H., Jeong, B.C., Kwak, C. et al. A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men. World J Urol 26, 395–400 (2008). https://doi.org/10.1007/s00345-008-0264-1

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  • DOI: https://doi.org/10.1007/s00345-008-0264-1

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