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Association of EMMPRIN and fascin expression in renal cell carcinoma: correlation with clinicopathological parameters

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Abstract

EMMPRIN and fascin are important factors in tumor invasion and progression. We tested the hypothesis that expression of EMMPRIN and fascin correlate with clinicopathological parameters of renal cell carcinoma (RCC). Immunohistochemical analysis of EMMPRIN and fascin were performed in tissue microarrays of 100 surgical specimens, including 35 clear-cell RCC (CRCC), 21 clear-cell RCC with granular differentiation (GRCC), 12 chromophobe RCC (ChRCC), 8 papillary RCC (PRCC), 9 carcinoma of the collecting duct of Bellini (CDC), 10 clear-cell RCC with sarcomatoid differentiation (SRCC), and 6 metastatic RCC. Average immunoscores of EMMPRIN were 100.8 in CRCC, 195.2 in GRCC, 298.4 in ChRCC, 219.2 in PRCC, 186.1 in CDC, 226.9 in SRCC, and 151.7 in metastatic RCC. Among all included cases, average EMMPRIN immunoscores were 84.6 in grade I, 130.4 in grade II, 184.3 in grade III, and 223.5 in grade IV. Additionally, average immunostaining scores of fascin were 53.6 in CRCC, 289.3 in GRCC, 193.3 in ChRCC, 151.8 in PRCC, 181.3 in CDC, 275.4 in SRCC, and 131.7 in metastatic RCC. Average fascin immunoscores were 59.3 in grade I, 91.6 in grade II, 130.2 in grade III, and 194.7 in grade IV. Higher EMMPRIN and fascin immunoscores also correlated significantly with TNM stages and survival rates in RCC. Significant correlation was found between EMMPRIN and fascin expression. In conclusion, higher expression of EMMPRIN and fascin correlate significantly with histological grades, clinical stages, and survival rates of RCC

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Acknowledgment

This study was supported by grants from National Science Counsel, NSC95-2320-B-016-024, and Tri-Service General Hospital, TSGH-C95-16-S05, Taiwan, R.O.C.

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Authors and Affiliations

  1. Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan

    Wen-Chiuan Tsai, Lai-Fa Sheu, Shin Nieh, Cheng-Ping Yu, Ann Chen & Jong-Shiaw Jin

  2. Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan

    Gung-Huan Sun

  3. Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan

    Yeh-Feng Lin

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  1. Wen-Chiuan Tsai
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  2. Lai-Fa Sheu
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  3. Shin Nieh
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  8. Jong-Shiaw Jin
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Correspondence to Jong-Shiaw Jin.

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Tsai, WC., Sheu, LF., Nieh, S. et al. Association of EMMPRIN and fascin expression in renal cell carcinoma: correlation with clinicopathological parameters. World J Urol 25, 73–80 (2007). https://doi.org/10.1007/s00345-006-0110-2

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  • DOI: https://doi.org/10.1007/s00345-006-0110-2

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