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Immune functional impacts of oyster peptide-based enteral nutrition formula (OPENF) on mice: a pilot study

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Abstract

Oyster peptides were produced from Crassostrea hongkongensis and used as a new protein source for the preparation of an oyster peptide-based enteral nutrition formula (OPENF). Reserpineinduced malabsorption mice and cyclophosphamide-induced immunosuppression mice were used in this study. OPENF powder is light yellow green and has a protein-fat-carbohydrate ratio of 16:9:75 with good solubility in water. A pilot study investigating immune functional impacts of the OPENF on mice show that the OPENF enhanced spleen lymphocyte proliferation and the activity of natural killer (NK) cells in BALB/c mice. Furthermore, OPENF can improve intestinal absorption, increase food utilization ratio, and maintain the normal physiological function of mice. These results suggest that oyster peptides could serve as a new protein source for use in enteral nutrition formula, but more importantly, also indicate that OPENF has an immunostimulating effect in mice.

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Authors and Affiliations

  1. Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China

    Bingna Cai  (蔡冰娜), Jianyu Pan  (潘剑宇), Peng Wan  (万鹏) & Huili Sun  (孙恢礼)

  2. Bureau of Science and Technology for Resource and Environment, Chinese Academy of Sciences, Beijing, 100864, China

    Yuantao Wu  (吴园涛)

  3. University of Chinese Academy of Sciences, Beijing, 100049, China

    Bingna Cai  (蔡冰娜), Peng Wan  (万鹏) & Huili Sun  (孙恢礼)

Authors
  1. Bingna Cai  (蔡冰娜)
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  2. Jianyu Pan  (潘剑宇)
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  3. Yuantao Wu  (吴园涛)
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  4. Peng Wan  (万鹏)
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  5. Huili Sun  (孙恢礼)
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Corresponding author

Correspondence to Huili Sun  (孙恢礼).

Additional information

Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology PromotionSpecial Program of Guangdong Province (No. A2009009-035(a))

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Cai, B., Pan, J., Wu, Y. et al. Immune functional impacts of oyster peptide-based enteral nutrition formula (OPENF) on mice: a pilot study. Chin. J. Ocean. Limnol. 31, 813–820 (2013). https://doi.org/10.1007/s00343-013-2311-z

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  • DOI: https://doi.org/10.1007/s00343-013-2311-z

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