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Synthesis of Au NPs with multiple detection functions based on MoO3-x nanosheets

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Abstract

In this article, a new method for preparing gold nanoparticles (Au NPs) from MoO3-x is developed. First, MoO3-x, which was prepared by stripping the intercalation layer with ultrapure water, not only acted as a sacrificial template but also acted as a charge transfer carrier during the synthesis of gold nanoparticles. The successfully prepared Au NPs showed high sensitivity in surface-enhanced Raman spectroscopy (SERS) sensitivity, for instance a limit of detection (LOD) down to 3.75 × 10–8 M for Rhodamine 6G (R6G) and 3.3 × 10–11 M for malachite green (MG). The feasibility of the material for the detection of MG in lake water and tap water was also confirmed. For Fluorescence assay, the LOD of Flavin Adenine Dinucleotide (FAD) can be as low as 2.17 × 10–8 M, indicating that the prepared Au NPs have excellent potential in Fluorescence assay. The feasibility of the material for the detection of FAD in normal human and breast cancer patient sera was also confirmed. Finally, the cytotoxicity of Au NPs was investigated, showing that the prepared Au NPs has good biocompatibility.

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Acknowledgements

We are grateful for the support by Fujian Provincial Department of Science and Technology guiding Project (2020Y0019); Industry-university Cooperation Project of Fujian Provincial Department of Science and Technology (2020N5006); Achievement Transformation Project of Fuzhou Science and Technology Bureau (2020-GX-20); Fushimei agricultural and rural maker space [Minke xing (2019) No.2]; Innovative Research Team in Science and Technology in Fujian Province University.

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  1. Ruiyun You

    Present address: College of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Key Laboratory of Polymer Materials, Fujian Normal University, Fuzhou, 350007, China

Authors and Affiliations

  1. College of Chemistry and Materials Science, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Key Laboratory of Polymer Materials, Fujian Normal University, Fuzhou, 350007, China

    Yuqin Liao, Min Fan, Qiutian She, Qian Huang, Sirui Han, Huanyu Xie & Yudong Lu

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Contributions

YL: investigation, writing—original draft. MF: resources, writing—review and editing. QS: investigation, methodology, writing—review and editing. QH: formal analysis. SH: resources, formal analysis. HX: investigation, methodology. RY: writing—review and editing. YL: supervision, funding acquisition, resources.

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Correspondence to Ruiyun You or Yudong Lu.

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Liao, Y., Fan, M., She, Q. et al. Synthesis of Au NPs with multiple detection functions based on MoO3-x nanosheets. Appl. Phys. A 128, 360 (2022). https://doi.org/10.1007/s00339-022-05486-0

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