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A highly sensitive electrochemical sensor for theophylline based on dopamine-melanin nanosphere (DMN)–gold nanoparticles (AuNPs)-modified electrode

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Abstract

Herein, a facile electrochemical sensor was proposed for accurate determination of theophylline (TP) based on dopamine-melanin nanosphere (DMN)–gold nanoparticles (AuNPs) nanocomposite-modified glass carbon electrode. The dopamine-melanin nanospheres (DMNs) were prepared facilely by a chemical route. The well-dispersed Au nanoparticles were anchored on the surface of DMNs via in situ reduction of Au precursor. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were adopted to investigate the electrochemical oxidation behavior of TP at the DMN-AuNPs-modified electrode. In 0.1 M H2SO4 medium, the developed electrochemical sensor displayed excellent electrocatalytic activity toward the oxidation of TP. The sensor showed high sensitivity for the determination of TP under the optimized conditions. The oxidation peak current of TP exhibited good linear relationship with its concentration in the range from 50 nM to 2 μM with detection limit of 9.6 nM (S/N = 3). The modified electrode showed excellent selectivity, long-term stability, and good repeatability for the determination of TP. This proposed method was successfully applied to determine the content of TP in tea and biological samples with acceptable recoveries.

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Acknowledgements

This work was financially supported by National Natural Science Foundation of China (No. U1704153), 1000 Talents Program of Zhongyuan (ZYQR201912153), Plan for Young Excellent Teachers in Universities of Henan Province (No. 2017GGJS100), the key Scientific Research Projects in University of Henan Province (21A150050), Nanhu Scholars Program for Young Scholars of XYNU.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, People’s Republic of China

    Hongding Zhang, Sifei Wu, Hai-Bo Wang & Yan-Ming Liu

  2. Xinyang Branch, Henan Province Institute of Boiler and Pressure Vessel Safety Testing, Xingyang, 464000, People’s Republic of China

    Zhenhua Xing

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  1. Hongding Zhang
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  2. Sifei Wu
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  3. Zhenhua Xing
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Correspondence to Hongding Zhang or Hai-Bo Wang.

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Zhang, H., Wu, S., Xing, Z. et al. A highly sensitive electrochemical sensor for theophylline based on dopamine-melanin nanosphere (DMN)–gold nanoparticles (AuNPs)-modified electrode. Appl. Phys. A 127, 844 (2021). https://doi.org/10.1007/s00339-021-04968-x

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