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In-vitro antibacterial and anti-biofilm efficiencies of chitosan-encapsulated zinc ferrite nanoparticles

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Abstract

Recently, nanoparticle (NP)-encapsulated surfaces have received remarkable attention as a promising antimicrobial alternate. Thereby, the present investigation focuses to develop chitosan-encapsulated zinc ferrite nanoparticles (CT-ZnFe2O4 NPs) for antibacterial and anti-biofilm efficiencies against the range of pathogens. In this study, ZnFe2O4 NPs synthesized by a sol–gel auto-combustion method are coated with a natural CT polymer. Agar well diffusion, growth kinetics and colony-forming unit measurement studies demonstrated that the CT-ZnFe2O4 NPs behave excellent antibacterial agent against both Gram-positive and Gram-negative bacteria. Subsequently, their inhibitory effect on biofilm formation and removal of established biofilm are also been evaluated. Obtained results demonstrated that the CT-ZnFe2O4 NPs inhibit the biofilm formation more than 65% and reduce established biofilm up to 50% at a respective minimum inhibitory concentration (MIC). Promising findings of this study suggest an exciting opportunity in antimicrobial therapy like antibacterial coatings that wound care and target drug delivery in biofilm treatment.

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Acknowledgements

The authors would like to thanks Director of UGC-DAE-CSR for allowing the EDAX facility. Thanks to Dr. D. M. Phase and V. K. Ahire for allowing time slot for performing the experiments and providing data.

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Authors and Affiliations

  1. School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, 431606, India

    Rashmi P. Sharma & Ramjan M. Mulani

  2. School of Physical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, 431606, India

    Siddheshwar D. Raut & Rajaram S. Mane

  3. Department of Botany, DSM’S ACS, College, District Parbhani, Jintur, Maharashtra, 431509, India

    Ambadas S. Kadam

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  1. Rashmi P. Sharma
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Sharma, R.P., Raut, S.D., Kadam, A.S. et al. In-vitro antibacterial and anti-biofilm efficiencies of chitosan-encapsulated zinc ferrite nanoparticles. Appl. Phys. A 126, 824 (2020). https://doi.org/10.1007/s00339-020-04007-1

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