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γ-Fe2O3/Gd2O3-chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies

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Abstract

We report a facile and friendly to the environment method for the preparation of superparamagnetic γ-Fe2O3/Gd2O3-chitosan nanocomposite for magnetic hyperthermia application. The nanocomposite was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer, Scanning electron microscopy and Energy-dispersive X-ray spectroscopy (EDAX). In addition, the heating efficiency and biocompatibility with human cells are reported. XRD patterns indicated that the most dominant crystalline phase is γ-Fe2O3with the presence of chitosan in the coated sample. FT-IR and EDAX confirmed the presence of chitosan on the surface of the nanostructure. Magnetic measurements showed the superparamagnetic behavior with decrease in saturation after coating due to diamagnetic nature of chitosan. This behavior is corroborated by the successfully fitting into Langevin function for paramagnetic materials. The specific absorption rate under an alternating magnetic field is investigated as a function of the concentration and amplitude of the applied magnetic field. A mean heating efficiency of 35 W/g is obtained for concentration of 15 mg/ml at 332 kHz and 170 Oe. It was found that the heating efficiency of the nanocomposite can be tuned by changing parameters such as concentration and amplitude of applied AC magnetic field. Cell viability assay of coated nanocomposite showed low cytotoxic effect on A549 cells line (human alveolar epithelial). In overall, the prepared nanocomposite can be used as potential candidate for magnetic hyperthermia application due to their superparamagnetic nature, heating ability and biocompatibility with human cells.

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References

  1. A. Jordan, P. Wust, H. Fahling, W. John, A. Hinz, R. Felix, Int. J. Hyperth. 9, 51–68 (1993)

    Google Scholar 

  2. O.M. Lemine, K. Omri, L. El Mir, V. Velasco, P. Crespo, P. De Presa, H. Bouzid, A. Youssif, A. Hajry, J. Alloys Compd. 607, 125–131 (2014)

    Google Scholar 

  3. P. De la Presa, Y. Luengo, M. Multigner, R. Costo, M.P. Morales, G. Rivero, A. Hernando, J. Phys. Chem. C 116, 25602–25610 (2012)

    Google Scholar 

  4. R.A. Bohara, N.D. Thorat, A.K. Chaurasi, S.H. Pawar, RSC Adv. 58, 47225 (2015)

    Google Scholar 

  5. E. Kita, S. Hashimoto, T. Kayano, M. Minagawa, H. Yanagihara, M. Kishimoto, K. Yamada, T. Oda, N. Ohkohchi, T. Takagi, T. Kanamori, Y. Ikehata, I. Nagano, J. Appl. Phys. 107, 09B321–09B321 (2010)

    Google Scholar 

  6. K.T. Arul, E. Manikandan, P.P. Murmu, J. Kennedy, M. Henini, J. Alloys Compd. 720, 395–400 (2017)

    Google Scholar 

  7. X.N. Pham, T.P. Nguyen, T.N. Pham, T.T.N. Tran, T.V.T. Tran, Adv. Nat. Sci. Nanosci. Nanotechnol. 7, 045010 (2016)

    ADS  Google Scholar 

  8. Qu Jingmiao, G. Liu, Y. Wang, R. Hong, Adv. Powder Technol. 21, 461–467 (2010)

    Google Scholar 

  9. P.B. Shete, R.M. Patil, N.D. Thorat, A. Prasad, R.S. Ningthoujam, S.J. Ghosh, S.H. Pawar, Appl. Surf. Sci. 288, 149–157 (2014)

    ADS  Google Scholar 

  10. N.D. Thorat, S.V. Otari, R.M. Patil, R.A. Bohar, H.M. Yadav, V.B. Koli, A.K. Chaurasia, R.S. Ningthoujam, Dalton Trans. 43, 17343–17351 (2014)

    Google Scholar 

  11. N.D. Thorat, O.M. Lemine, R.A. Bohara, K. Omri, L.E. Mir, S.A.M. Tofail, Phys. Chem. Chem. Phys. 18, 21331–21339 (2016)

    Google Scholar 

  12. F.J. Shahidi, K.V. Arachchi, Y. Yeon, J. Food Sci. Technol. 10, 37–51 (1999)

    Google Scholar 

  13. G. Gorrasi, A. Sorrentino, Green Chem. 17, 2610–2625 (2015)

    Google Scholar 

  14. W. Zhang, X. Li, R. Zou, H. Wu, H. Shi, S. Yu, Y. Liu, Sci. Rep. 5, 11129 (2015)

    ADS  Google Scholar 

  15. P. Scherrer, Nachr. Ges. Wiss. Göttingen 26, 98–100 (1918)

    Google Scholar 

  16. J.I. Langford, A.J.C. Wilson, J. Appl. Cryst. 11, 102–113 (1978)

    Google Scholar 

  17. V. Uvarov, I. Popov, Mater. Charact. 85, 111 (2013)

    Google Scholar 

  18. N.M. Julkapli, Z. Ahmad, H.M. Akil, AIP Conf. Proc. 1202, 106 (2010)

    ADS  Google Scholar 

  19. F. Ansari, A. Sobhani, M. Salavati-Niasari, J. Magn. Magn. Mater. 410, 27–33 (2016)

    ADS  Google Scholar 

  20. M. Farahmandjou, F. Soflaee, Phys. Chem. Res. 3, 191–196 (2015)

    Google Scholar 

  21. J.G. Kang, B.K. Min, Y. Sohn, Ceram. Int. 41, 1243–1248 (2015)

    Google Scholar 

  22. B. Zhao, Y. Wang, H. Guo, J. Wang, Y. He, Z. Jiao, M. Wu, Mater. Sci. Poland 25, 1143–1148 (2007)

    Google Scholar 

  23. S.G. Anicuta, L. Dobre, M. Stroescu, I. Jipa, Analele UniversităŃii din Oradea Fascicula: Ecotoxicologie, Zootehnie si Tehnologii de Industrie Alimentară, 2010

  24. R.M. Patil, P.B. Shete, N.D. Thorat, S.V. Otari, K.C. Barick, A. Prasad, R.S. Ningthoujam, B.M. Tiwale, S.H. Pawar, J. Magn. Magn. Mater. 355, 22 (2014)

    ADS  Google Scholar 

  25. K. Kaviyarasu, N. Geetha, S. Sivaranjani, A. Ayeshamariam, J. Kennedy, R. Ladchumananandasiivam, U.U. Gomes, M. Maaza, Mater. Sci. Eng. C 74, 325–333 (2017)

    Google Scholar 

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Authors and Affiliations

  1. Department of Physics, College of Sciences, Imam Mohammad Ibn Saud Islamic University (IMISU), Riyadh, 11623, Saudi Arabia

    O. M. Lemine, Amal Alanazi, S. Abu Alrub & A. Alkaoud

  2. Department of Physics, Faculty of Science, University Putra Malaysia (UPM), 43400, Serdang, Selangor, Malaysia

    Emmellie Laura Albert & Che Azurahanim Che Abdullah

  3. Material Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia (UPM), 43400, Serdang, Selangor, Malaysia

    Emmellie Laura Albert & Che Azurahanim Che Abdullah

  4. Department of Physics, Faculty of Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    M. Hjiri

  5. Center of Nanotechnology, King Abdulaziz University, Jeddah, Saudi Arabia

    M. Hjiri

  6. Unité de Chimie Moléculaire et Environnement (UCME), Département de Chimie, Faculté des Sciences et Techniques, Université de Nouakchott Al Aasriya (UNA), Nouakchott 880, Nouakchott, Mauritania

    Mohamed Ould M’hamed

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  1. O. M. Lemine
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  2. Amal Alanazi
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  3. Emmellie Laura Albert
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  8. Che Azurahanim Che Abdullah
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Lemine, O.M., Alanazi, A., Albert, E.L. et al. γ-Fe2O3/Gd2O3-chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies. Appl. Phys. A 126, 471 (2020). https://doi.org/10.1007/s00339-020-03649-5

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  • DOI: https://doi.org/10.1007/s00339-020-03649-5

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