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Surface-enhanced Raman scattering of 4-mercaptobenzoic acid and hemoglobin adsorbed on self-assembled Ag monolayer films with different shapes

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Abstract

Polyvinylpyrrolidone (PVP)-protected silver nanostructures of various shapes, including nanocubes, nanospheres, and hybrid shapes with nanospheres and nanorods, on the surface of glass or Si substrates (PVP-Ag films) are prepared by using electrostatic self-assembly. With 4-mercaptobenzoic acid (4-MBA) as a probe molecule, it is demonstrated that the PVP-protected silver nanocubes films (PVP-Ag NCs) have better surface-enhanced Raman scattering (SERS) activity with an order of magnitude larger enhancement factors (EF) than the PVP-protected silver nanospheres films and the PVP-protected silver hybrid shapes films, which is confirmed by our numerical simulations. The EF of 4-MBA on the PVP-Ag NCs film are up to ~5.38 × 106, and the detection limit is at least down to ~10−8 M. The uniformity and reproducibility of the SERS signals on PVP-Ag NCs film are tested by point-to-point and batch-to-batch measurements. Meanwhile, the PVP-Ag films are also shown to be an excellent SERS substrate with good biocompatibility for hemoglobin detection. It is shown that the PVP-Ag NCs films can be used as excellent SERS substrate with good activity, uniformity, reproducibility, and biocompatibility and are promising for a myriad of chemical and biochemical sensing applications.

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Acknowledgments

This work was supported by the National Science Foundation of China (Grant No. 11104252), by the Ministry of Education of China (Grant No. 20114101110003), by the fund for Science & Technology innovation team of Zhengzhou (No. 112PCXTD337), by the Science and Technology Program of Henan Province (Grant No. 112102310543), by the Natural Science Foundation of Henan Educational Committee (Grant Nos. 12A140002 and 13A140693), and by the fund for Science and Technology development of Zhengzhou (Grant No. 20130825).

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Authors and Affiliations

  1. Key Laboratory of Materials Physics of Ministry of Education of China, School of Physical Science and Engineering, Zhengzhou University, Zhengzhou, 450052, China

    Shuangmei Zhu, Chunzhen Fan, Junqiao Wang, Jinna He & Erjun Liang

  2. College of Science, Henan Institute of Engineering, Zhengzhou, 451191, China

    Shuangmei Zhu

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  1. Shuangmei Zhu
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  2. Chunzhen Fan
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  3. Junqiao Wang
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Correspondence to Erjun Liang.

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Zhu, S., Fan, C., Wang, J. et al. Surface-enhanced Raman scattering of 4-mercaptobenzoic acid and hemoglobin adsorbed on self-assembled Ag monolayer films with different shapes. Appl. Phys. A 117, 1075–1083 (2014). https://doi.org/10.1007/s00339-014-8548-3

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  • DOI: https://doi.org/10.1007/s00339-014-8548-3

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