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Zerebrovaskuläre Ereignisse

Risiken der zervikalen Manipulationsbehandlung im Licht neuerer Erkenntnisse - ein Überblick

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Zusammenfassung

Vieles deutet auf einen kausalen Zusammenhang zwischen Anomalien der arteriellen Gefäßstruktur und zerebrovaskulären Ereignissen hin, wobei erhöhte Homozysteinspiegel eine besondere Rolle spielen. Bezogen auf die zervikale Manipulationsbehandlung lassen die Ergebnisse der vorliegenden Arbeit darauf schließen, dass die Fragilität der arteriellen Gefäßwand im zerebrovaskulären Stromgebiet als Hauptursache arterieller Dissektionen anzusehen und weitaus bedeutender ist als irgendein durch die Manöver des behandelnden Therapeuten ausgelöste Trauma.

Das aktuelle Risiko zerebrovaskulärer Ereignisse, die in einem direkten Zusammenhang mit einer spinalen Manipulationsbehandlung stehen, ist verglichen mit den Risiken des alltäglichen Lebens bzw. den Risiken, die von der Allgemeinheit bei medizinischen Behandlungen akzeptiert werden, als gering einzuschätzen. Die Verbreitung von Risikoschätzungen in Verbindung mit einer chiropraktischen Therapie ohne Daten, welche dies eindeutig belegen, ist für die Bevölkerung sicherlich nicht dienlich, sondern eher schädlich. Mit der Bestimmung des Homozysteinspiegels steht eine klinische Methode zur Verfügung, die das aktuelle Risiko zerebrovaskulärer Ereignisse weiter reduzieren könnte. Zum gegenwärtigen Zeitpunkt scheint die Bestimmung des Homozysteinspiegels die überzeugendste Methode zur Klassifikation von Patienten zu sein, die das höchste Risiko für ein zerebrovaskuläres Ereignis bei alltäglichen Tätigkeiten bzw. bei einer zervikalen Manipulationsbehandlung aufweisen.

Abstract

Many signs point to intrinsic aberrations of arterial structure as an underlay for CVAs, many of them brought on by elevated levels of homocysteine. When applied to cervical manipulations, the body of evidence outlined in this report suggests that it is the inherent fragility of the arterial wall of the cerebrovascular system rather than any trauma associated with maneuvers performed by the attending physician that is the major culprit in the causation of arterial dissections. The actual risk of CVAs directly attributable to spinal manipulation can be seen to be far lower than is generally assumed when it is compared with everyday lifestyle risks and those inherent in medical treatments that are widely accepted by the public. Certainly the propagation of estimated risk levels of visits to the chiropractor's office without adequate justification from data does not constitute a useful service to the public; indeed, it is just the opposite. It appears that the determination of homocysteine levels as a clinical tool would afford the chiropractic physician a means of bringing down the actual risks of CVAs to even lower levels than those previously reported. In this regard, determination of homocysteine levels currently appears to be the most plausible means of finding which patients are most at risk of CVAs resulting from routine activities, quite apart from cervical manipulations.

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Literatur

  1. Beatty RA (1977) Dissecting hematoma of the internal carotid artery following chiropractic cervical manipulation. J Trauma 17:248–249

    Google Scholar 

  2. Bill Carroll Show (2002) CFRB 1010 radio, February 6

  3. Bin Saeed A, Shuaib A, Al-Sulaiti G, Emery D (2000) Vertebral artery dissection: warning symptoms, clinical features and prognosis in 26 patients. Can J Neur Sci 27:292–296

    Google Scholar 

  4. Bolton PS, Stick PE, Lord RSA (1989) Failure of clinial tests to predict cerebral ischemia before neck manipulation. J Man Phys Ther 12:304–307

    Google Scholar 

  5. Brody J (2001) When simple actions ravage arteries. New York Times, April 30

  6. Carey PF (1993) A report on the occurrence of cerebral vascular accidents in chiropractic practice. J Can Chiropract Ass 57:104–106

    Google Scholar 

  7. Carey TS, Garrett J, Jackman A, McLaughlin C, Fryer J, Smucker DR (1995) North Carolina Back Pain Project. The outcomes and costs of care for acute low back pain among patients seen by primary care practitioners, chiropractors, and orthopedic surgeons. N Engl J Med 333:913–917

    Google Scholar 

  8. Charplot P, Bescond A, Augler T et al. (1998) Hyperhomocysteinemia induces elastolysis in minipig arteries: Structural consequences, arterial site specificity and effect of captoprilhydrochlorothiazide. Matrix Biology 17:559–574

    Google Scholar 

  9. Dabbs V, Lauretti W (1995) A risk assessment of cervical manipulation vs NSAIDs for the treatment of neck pain. J Man Phys Ther 18:530–536

    Google Scholar 

  10. Degenhardt BF, Kuchera ML (1994) Efficacy of osteopathic evaluation and manipulative treatment in reducing the morbidity of otitis media in children. J Am Osteopath Ass 94:673

    Google Scholar 

  11. Deyo RA, Cherkin DC, Loesser JD, Bigos SJ, Ciol MA (1992) Morbidity and mortality in association with operations on the lumbar spine: The influence of age, diagnosis, and procedure. J Bone Joint Surg Am 74:536–543

    Google Scholar 

  12. Dinman BD (1980) The reality and acceptance of risk. J Am Med Ass 244:1226–1228

    Google Scholar 

  13. Dvorak J, Orelli F (1985) How dangerous is manipulation of the cervical spine? Man Med 2:1–4

    Google Scholar 

  14. Evenson B (2002) National Post, February 7

  15. Fallon J (1997) The role of chiropractic adjustment in the care and treatment of 332 children with otitis media. J Clin Chiropract Ped 2:167–183

    Google Scholar 

  16. Ferezy JS (1988) Neural ischemia and cervical manipulation: An acceptable risk. ACA Journal of Chiropractic 22:61–63

    Google Scholar 

  17. Foye PM, Najar MP, Camme A Jr et al. (2002) Prospective study of pain, dizziness, and central nervous system blood blow in cervical extension: Vascular correlations to beauty parlor stroke syndrome and salon sink radiuculopathy. Am J Phys Med Rehab 81:395–399

    Google Scholar 

  18. Frantzen F, Faaren AL, Alfheim I, Nordhei AK (1998) Enzyme conversion immunoassay for determining total homocysteine in plasma or serum. Clin Chem 44:311–316

    Google Scholar 

  19. Froehle RM (1996) Ear infection: A retrospective study examining improvement from chiropractic care and analyzing for influencing factors. J Man Phys Ther 19:169–177

    Google Scholar 

  20. Gallai V, Caso V, Paciaroni M, Cardaioli G, Arning E, Bottiglieri T, Pernetti L (2001) Mild hyperhomosyct(e)inemia: A possible risk factor for cervical artery dissection. Stroke 32:714–718

    Google Scholar 

  21. Giroud M, Fayolle H, Andre N et al. (1994) Incidence of internal carotid artery dissection in the community of Dijon. J Neur Neurosurg Psych 57:1443

    Google Scholar 

  22. Good C (2003) Letters to the editor. Journal of Manipulative and Physiological Therapeutics, 26: Submitted for Publication

  23. Graham IM, Daley LE, Refsum HM et al. (1997) Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project. J Am Med Ass 277:1775–1781

    Google Scholar 

  24. Haldeman S (1996) Chiropractic complications. Neurology 46:885

  25. Haldeman S, Carey P, Townsend M, Papadopoulos C (2001) Arterial dissections following cervical manipulation: The chiropractic experience. Can Med Ass J 165:905–906

    Google Scholar 

  26. Haldeman S, Chapman-Smith D, Peterson DM (1993) Guidelines for chiropractic quality assurance and practice parameters. Aspen, Gaithersburg/MD, pp 170–172

  27. Haldeman S, Kohlbeck FJ, McGregor M (2002) Unpredictability of cerebrovascular ischemia associated with cervical spine manipulation therapy. Spine 27:49–55

    Google Scholar 

  28. Hamburg J (2002) Medical Minute. WOR AM 710 radio, February 22

  29. Harker LA, Slichter J, Scott CR, Russell R (1974) Homocysteinemia: Vascular injury and arterial thrombosis. N Engl J Med 291:537–543

    Google Scholar 

  30. Haynes MJ, Cala LA, Melsom A, Mastaglia FL, Milne N, McGeachie JK (2002) Vertebral arteries and cervical rotation: Modeling and magnetic resonance angiography studies. J Man Phys Ther 25:370–383

    Google Scholar 

  31. Henderson DJ, Cassidy JD (1988) Vertebral artery syndrome. In: Vernon H (Hrsg) Upper cervical syndrome: Chiropractic diagnosis and treatment. Williams & Wilkins, Baltimore, pp 195–222

  32. Horowitz SH (1994) Peripheral nerve injury and causalgia secondary to routine venipuncture. Neurology 44:962–964

    Google Scholar 

  33. Hufnagel A, Hammers A, Schonle PW, Bohm KD, Leonhardt G (1999) Stroke following chiropractic manipulation of the cervical spine. J Neurol 246:683–688

    Google Scholar 

  34. Hurwitz EL, Aker PD, Adams AH, Meeker WC, Shekelle PG (❚) Manipulation and mobilization of the cervical spine: A systematic review of the literature. Spine 21:1746–1760

  35. Jackson SH (1973) The reaction of homocysteine with aldehyde: An explanation of the collagen defects in homocystinuria. Clinica Chimica Acta 45:215–217

    Google Scholar 

  36. Jaroff L (2002) Back off, chiropractors! TIME.com, February 27

  37. Jaskoviak PA (1980) Complications arising from manipulation of the cervical spine. J Man Phys Ther 3:213–219

    Google Scholar 

  38. Kang AH, Trelstad RL (1973) A collagen defect in homocystinuria. J Clin Invest 52:2571–2578

    Google Scholar 

  39. Klougart N, LeBouef-Yde C, Rasmussen LR (1996) Safety in chiropractic practice, Part II: Treatment in the upper neck and the rate of cerebrovascular incidents. J Man Phys Ther 19:563–569

    Google Scholar 

  40. Lee KP, Carlini WG, McCormick GF, Walters GW (1995) Neurologic complications following chiropractic manipulation: A survey of California neurologists. Neurology 45:1213–1215

    Google Scholar 

  41. Lehninger AL, Nelson DL, Cox MM (1993) Principles of Biochemistry. Worth, New York/NY, pp 524–526

  42. Lenz SR, Sobey CG, Piegors DJ et al. (1996) Vascular dysfunction in monkey with diet-induced hyperhomocysteinemia. J Clin Invest 98:24–29

    Google Scholar 

  43. McCully KS (1969) Vascular pathology of homocysteinemia: Implications for pathogenesis of arteriosclerosis. Am J Pathol 56:111–128

    Google Scholar 

  44. McGregor M, Haldeman S, Kohlbeck FJ (1995) Vertebrobasilar compromise associated with cervical manipulation. Topics in Clinical Chiropractic 2:63–73

    Google Scholar 

  45. Meeker WC, Haldeman S (2002) Chiropractic: a profession at the crossroads of mainstream and alternative medicine. Ann Int Med 136:216–227

    Google Scholar 

  46. Meeker WC, Mootz RD, Haldeman S (2002) Back to basics.The state of chiropractic research. Topics in Clinical Chiropractic 9:1–13

  47. National Chiropractic Mutual Insurance Company (1991–1993) Unpublished case records.

  48. National Chiropractic Mutual Insurance Company (1997) Type of loss study: Malpractice only for loss year 1995. Des Moines, IA: National Chiropractic Mutual Insurance Company as reported in Jagbandhansingh, MP. Most common causes of chiropractic malpractice lawsuits. J Man Phys Ther 20:60–64

    Google Scholar 

  49. NN (2002) A different way to heal. Episode of Scientific American Frontiers Public Broadcasting System telecast, June 4

  50. Norris JW, Beletsky V, Nadareishvilli ZG, Canadian Stroke Consortium (2000) Can Med Ass J 163:38–40

  51. Nygard O, Nordehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337:230–236

    Google Scholar 

  52. Parenti G, Orlandi G, Bianchi M, Renna M, Martini A, Murri L (1999) Vertebral and carotid artery dissection following chiropractic cervical manipulation. Neurosurg Rev 22:127–129

    Google Scholar 

  53. Patijn J (1991) Complications in manual medicine: A review of the literature. Man Med 6:89–92

    Google Scholar 

  54. Peters M, Bohn J, Thomke F et al. (1995) Dissection of the internal carotid artery after chiropractic manipulation of the neck. Neurology 45:496–500

    Google Scholar 

  55. Pezzini A, Del Zotto E, Archetti S et al. (2002) Plasma homocysteine concentration, C677T MTHFR genotype, and 844-ins68 bp genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke. Stroke 33:664–669

    Google Scholar 

  56. Pietzsch J, Julius U, Hanefeld M (1997) Rapid determination of total homocysteine in human plasma by using N(O,S)-ethoxycarbonyl ethyl ester derivatives and gas chromatography-mass spectrometry. Clin Chem 43:2001–2004

    Google Scholar 

  57. Rahmani DJ, Rolland PH, Rosset E, Branchereau A, Garcon D (1997) Homocysteine induces synthesis of a serine elastase in arterial smooth muscle cells from multi-organ donors. Cardiovasc Res 34:597–602

    Google Scholar 

  58. Roebuck DJ (1994) Diagnostic imaging: Reversing the focus. Med J Australia 162:175

    Google Scholar 

  59. Rome PL (1999) Perspectives: An overview of comparative considerations of cerebrovascular accidents. Chiropract J Australia 29:87–102

    Google Scholar 

  60. Rosner A (2001) Chiropractic manipulation and stroke. Stroke 32:2207–2208

    Google Scholar 

  61. Rosner A (2003) Musculoskeletal research. In: Redwood DM, Cleveland C (Hrsg.) Fundamentals of Chiropractic. Churchill Livingstone, New York/N

  62. Rothwell DM, Bondy SJ, Williams JI (2001) Chiropractic manipulation and stroke: A population-based case-control study. Stroke 32:1054–1060

    Google Scholar 

  63. Seagroat V, Tan HS, Goldacre M, Bulstrode C, Nugent I, Gill L (1991) Effective total hip replacement: Incidence, emergency, readmission rate, and post-operative mortality. Br Med J 330:1431–1435

    Google Scholar 

  64. Selhub J, Jacques PF, Bostom AG et al. (1995) Association between plasma homocysteine concentrations and extracranial carotid artery stenosis. N Engl J Med 332:286–291

    Google Scholar 

  65. Shievink WT, Mokri B, Whisnant JP (1993) Internal carotid artery dissection in a community: Rochester, Minnesota, 1987–1992. Stroke 24:1678–1680

    Google Scholar 

  66. Shievink WT, Mokri, B, O'Fallon WM (1994) Recurrent spontaneous cervical-artery dissection. N Engl J Med 330:393–397

    Google Scholar 

  67. Shipchandler MT, Moore EG (1995) Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clin Chem 41:991–994

    Google Scholar 

  68. Stabler SP, Marcell PD, Podell ER, Allen RH (1987) Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Analytical Biochemistry 162:185–196

    Google Scholar 

  69. Stampfer MJ, Malinow R, Willett WC et al. (1992) A prospective study of plasma homycyst(e)ine and risk of myocardial infarction in US physicians. J Am Med Ass 268:877–881

    Google Scholar 

  70. Stremple JS, Boss DS, Davis CH, McDonald GO (1994) Comparison of post-operative mortality and morbidity in Veterans Affairs and nonfederal hospitals. J Surg Res S6:405–416

    Google Scholar 

  71. Symons BP, Herzog W (2002) Internal forces sustained by the vertebral artery during spinal manipulative therapy. J Man Phys Ther 25:504–510

    Google Scholar 

  72. Terrett AGJ (1995) Misuse of the literature by medical authors in discussing spinal manipulative therapy. J Man Phys Ther 18:203–210

    Google Scholar 

  73. Terrett AGJ (1996) Malpractice avoidance for chiropractors. 1. Vertebrobasilar stroke following manipulation. National Chiropractic Mutual Insurance Company, Des Moines/IA

  74. Terrett AGJ (2001) Current concepts in vertebrobasilar complications following spinal manipulation. NCMIC Group, Des Moines/IA

  75. Terrett AGJ, Kleynhans AM (1992) Cerebrovascular complications of manipulation. In Haldeman S (Hrsg.) Principles and Practice of Chiropractic. Appleton & Lange, Norwalk, pp 579–598

  76. Terrett AGL (1990) It is more important to know when not to adjust. Chiropractic Technique 2:1–9

    Google Scholar 

  77. Ueland PM, Refsum H, Stabler SP, Mainow MR, Anderson A, Allen RH (1993) Total homocysteine in plasma and serum: Methods and clinical applications. Clin Chem 39:1764–1779

    Google Scholar 

  78. Wald NJ, Watt HC, Law MR, Weir DG, McPartlin J, Scott JM (1998) Homocysteine and ischemic heart disease: Results of a prospective study with implications regarding prevention. Arch Int Med 158:862–867

    Google Scholar 

  79. Wall RT, Harlan JM, Harker LA, Striker GF (1980) Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury. Thromb Res 18:113–121

    Google Scholar 

  80. Woo KS, Chook P, Lolin YI et al. (1997) Hyperhomocysteinemia is a risk factor for endothelial dysfunction in humans. Circulation 96:2542–2544

    Google Scholar 

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Rosner, A.L. Zerebrovaskuläre Ereignisse. Manuelle Medizin 41, 215–223 (2003). https://doi.org/10.1007/s00337-003-0217-0

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