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Rat Chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers

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Abstract.

The rat Chromosome (Chr) 2 harbors several genes controlling tumor growth or development, blood pressure, and non-insulin-dependent diabetes mellitus. We report that the region (2q1) containing the mammary susceptibility cancer gene Mcs1 also harbors the genes encoding cyclin B1, interleukin 6 signal transducer (gp130), and proprotein convertase 1. We also generated 13 new anonymous microsatellite markers from Chr 2-sorted DNA. These markers, as well as a microsatellite marker in the cyclin B1 gene, were genetically mapped in combination with known markers. A cyclin B1-related gene was also cytogenetically assigned to rat Chr 11q22-q23.

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Authors and Affiliations

  1. Département de Biologie Moléculaire, Université Libre de Bruxelles, Rue des Chevaux, 67; B-1640 Rhode-Saint-Genèse, Belgium, , , , , , BE

    Claude Szpirer, Fadel Tissir, Michèle Rivière, Pascale Van Vooren, Johanna Kela, Françoise Lallemand, Philippe Gabant & Josiane Szpirer

  2. Laboratory of Health Effects Research, National Institutes of Public Health and The Environment, Bilthoven 3720 BA, The Netherlands, , , , , , NL

    Barbara Hoebee

  3. CMB-Genetics, Göteborg University, S-405 30 Gothenburg, Sweden, , , , , , SE

    Karin Klinga-Levan & Göran Levan

Authors
  1. Claude Szpirer
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  2. Fadel Tissir
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  3. Michèle Rivière
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  4. Pascale Van Vooren
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  5. Johanna Kela
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  6. Françoise Lallemand
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  7. Philippe Gabant
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  8. Barbara Hoebee
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  9. Karin Klinga-Levan
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  10. Göran Levan
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  11. Josiane Szpirer
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Received: 21 July 1998 / Accepted: 28 August 1998

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Szpirer, C., Tissir, F., Rivière, M. et al. Rat Chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers. 10, 30–34 (1999). https://doi.org/10.1007/s003359900937

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  • DOI: https://doi.org/10.1007/s003359900937

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