Skip to main content
SpringerLink
Log in

Comparative mapping of human Chromosome 2 identifies segments of conserved synteny near the bovine mh locus

  • Published:
Mammalian Genome Aims and scope Submit manuscript

Abstract.

The ``double-muscling'' (mh) locus has been localized to an interval between the centromere and the microsatellite marker TGLA44 on bovine Chromosome (Chr) 2 (BTA2). We identified segments of conserved synteny that correspond to this region of BTA2 by assigning large genomic clones containing bovine homologs of seven genes from the long arm of human Chr 2 (HSA2q). Polymorphic markers developed from these clones integrated the physical and linkage maps of BTA2 from 2q12 to 2q44 and extended genetic coverage towards the centromere. This comparative analysis suggests the mh locus resides on HSA2q near both the protein C and collagen type III alpha-1 genes. Overall, our data reveal a complex rearrangement of gene order between BTA2q12-44 and HSA2q14-37 that underscores the need to establish boundaries of conserved synteny when applying comparative mapping information to identify genes or traits of interest.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. U.S. Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center (MARC), P.O. Box 166, Spur 18D, Clay Center, Nebraska 68933-0166, USA, , , , , , US

    Tad S. Sonstegard, Nestor L. Lopez-Corrales, Steven M. Kappes, Craig W. Beattie & Timothy P.L. Smith

Authors
  1. Tad S. Sonstegard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nestor L. Lopez-Corrales
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Steven M. Kappes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Craig W. Beattie
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Timothy P.L. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 3 March 1997 / Accepted: 12 May 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sonstegard, T., Lopez-Corrales, N., Kappes, S. et al. Comparative mapping of human Chromosome 2 identifies segments of conserved synteny near the bovine mh locus. 8, 751–755 (1997). https://doi.org/10.1007/s003359900559

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s003359900559

Keywords

Search

Navigation