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Rat Chromosome 1: Regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map

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Abstract

Seven genes were regionally localized on rat Chromosome (Chr) 1, from 1p11 to 1q42, and two of these genes were also included in a linkage map. This mapping work integrates the genetic linkage map and the cytogenetic map, and allows us to orient the linkage map with respect to the centromere, and to deduce the approximate position of the centromere in the linkage map. These mapping data also indicate that the Slc9a3 gene, encoding the Na+/H+ exchanger 3, is an unlikely candidate for the blood pressure loci assigned to rat Chr 1. These new localizations expand comparative mapping between rat Chr 1 and mouse or human chromosomes.

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Author notes

  1. E. Stephanova

    Present address: Department of Cytology, University of Sofia, 1421, Sofia, Bulgaria

Authors and Affiliations

  1. Département de Biologie Moléculaire, Université Libre de Bruxelles, Rue des Chevaux, 67, B-1640, Rhode-Saint-Genèse, Belgium

    C. Szpirer, J. Szpirer, F. Tissir, E. Stephanova & P. Vanvooren

  2. Department of Laboratory Medicine, University of California, 94143-0134, San Francisco, California, USA

    T. W. Kurtz

  3. Department of Biochemistry, Vanderbilt University School of Medicine, 37232-0146, Nashville, Tennessee, USA

    N. Iwai & T. Inagami

  4. First Department of Internal Medicine, Shiga University of Medical Sciences, Tsukinowa Seta, Ohtsu-City, Japan

    N. Iwai

  5. Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

    M. Pravenec & V. Kren

  6. Institute of Biology, Charles University, Prague, Czech Republic

    M. Pravenec & V. Kren

  7. Department of Genetics, University of Gothenburg, S-413 90, Gothenburg, Sweden

    K. Klinga-Levan & G. Levan

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  1. C. Szpirer
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Szpirer, C., Szpirer, J., Tissir, F. et al. Rat Chromosome 1: Regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map. Mammalian Genome 8, 657–660 (1997). https://doi.org/10.1007/s003359900532

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  • DOI: https://doi.org/10.1007/s003359900532

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