References
Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (1990) Identification of transforming growth factor B family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci USA 87, 9843–9847
Derynck R (1994) Transforming growth factor (3. In The Cytokine Handbook 2nd ed. Angus Thompson ed. (Boston: Academic Press) pp 319–342
Derynck R, Rhee L, Chen EY, Tilburg AV (1987) Intron-exon structure of the human transforming growth factor-β precursor gene. Nucleic Acid Res 15, 3188–3189
Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ, Moses HL, Chen EY (1988) A new type of transforming growth factor-β TGF-β. EMBO J 7, 3737–3743
Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice JM, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM, Siracusa LD, Lyons KM, Derynck R, Hogan BLM, Coperland NG, Jemkins NA (1990) Chromosomal localization of seven members of the TGF-b superfamily suggests close linkage to several morphogenetic mutant loci. Genomics 6, 505–520
Feng JQ, Harris MA, Ghosh-Choudhury N, Feng M, Mundy GR, Harris SE (1994) Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. Biochim Biophys Acta 1218, 221–224
Feng JQ, Chen D, Cooney AJ, Tsai M-J, Harris MA, Tsai SY, Feng M, Mundy GR, Harris SE (1995) The mouse bone morphogenetic protein-4 gene. J Biol Chem 270, 28364–28373
Gitelman SE, Kobrin MS, Ye J-Q, Lopez AR, Lee A, Derynck R (1994) Recombinant vgr-l/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol 126, 1595–1609
Gitelman SE, Kirk M, Ye J-Q, Filvaroff EH, Kahn AJ, Derynck R (1995) Vgr-l/BMP-6 induces osteoblastic differentiation of pluripotent mesenchymal cells. Cell Growth Differ 6, 827–836
Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (1992) A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. Genomics 14, 759–762
Jones CM, Lyons KM, Hogan BLM (1991) Involvement of bone morphogenetic protein-4(BMP-4) and vgr-1 in morphogenesis and neurogenesis in the mouse. Development 111, 531–542
Kingsley DM (1994) The TGF-beta superfamily: new members, new reports, and new genetic tests of function in different organisms. Genes Dev 8, 133–146
Kingsley DM, Bland AE, Grubber JM, Marker PC, Russell LB, Copeland NG, Jenkins NA (1992) The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF-β superfamily. Cell 71, 399–410
Luo G, Hofmann C, Bronkers ALJJ, Sohocki M, Bradley A, Karsenty G (1995) BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9, 2808–2820
Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BLM, Derynck R (1989a) Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci USA 86, 4554–4558
Lyons KM, Pelton RW, Hogan BLM (1989b) Patterns of expression of murine Vgr-1 and BMP-2 RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev 3, 1657–1668
Lyons KM, Jones CM, Hogan BLM (1991) The DVR gene family in embryonic development. Trends Genet 7, 408–412
Ozkaynak E, Schnegelsberg PNJ, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (1992) Osteogenic protein-2: a new member of the transforming growth factor-b superfamily expressed early in embryogenesis. J Biol Chem 267, 25220–25227
Roberts AB, Sporn MB (1990) The transforming growth factor-betas. In Handbook of Experimental Pharmacology. Peptide Growth Factors and Their Receptors, M.B. Sporn, A.B. Roberts, eds. pp 419-472
St. Johnston RD, Hoffmann FM, Blackman RK, Segal D, Grimaila R, Padgett RW, Irick HA, Gelbart WM (1990) Molecular organization of the decapentaplegic gene in Drosophila melanogaster. Genes Dev 4, 1114–1127
Wall NA, Blessing M, Wright CVE, Hogan BLM (1993) Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J Cell Biol 120, 493–502
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gitelman, S.E., Kobrin, M., Lee, A. et al. Structure and sequence of the mouse bmp6 gene. Mammalian Genome 8, 212–214 (1997). https://doi.org/10.1007/s003359900391
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s003359900391