Abstract
A novel mouse gene, provisionally named Lxl, has been cloned and sequenced. Lxl most likely represents the mouse homolog of the rat gene OCT1, which encodes a polyspecific transmembrane transporter that is possibly involved in drug elimination. The LX1 predicted protein is highly hydrophobic, possesses twelve putative transmembrane domains, and also shares significant homology with members of the sugar transporter family, particularly the novel liver-specific transporter NLT. Lxl mRNA is expressed at high levels in mouse liver, kidney, and intestine, and at low levels in the adrenals and in lactating mammary glands. The Lxl gene maps very close to the imprinted 1gf2r/Mpr300 gene on mouse Chromosome (Chr) 17, in a region that is syntenic to human Chr 6q. Chr 6q has been previously associated with transient neonatal diabetes mellitus and breast cancer.
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The nucleotide sequences data reported in this paper have been submitted to the GenBank data library; accession numbers U38652 and U38913.
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Schweifer, N., Barlow, D.P. The Lxl gene maps to mouse Chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mammalian Genome 7, 735–740 (1996). https://doi.org/10.1007/s003359900223
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DOI: https://doi.org/10.1007/s003359900223