Skip to main content
Log in

Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2

  • Original Contribution
  • Published:
Mammalian Genome Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Adler, D.A., Quaderi, N.A., Brown, S.D.M., Chapman, V.M., Moore, J., Tate, P., Disteche, C. (1995). The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in mouse. Mamm. Genome, 6, 491–492.

    Article  CAS  Google Scholar 

  • Blanchard, M.M., Taillon-Miller, P., Novotny, P., Novotny, W. (1993). PCR buffer optimization with uniform temperature regimen to facilitate automation. PCR Methods Appl. 2, 234–240.

    PubMed  CAS  Google Scholar 

  • Brown, C.J., Flenniken, A.M., Williams, B.R.G., Willard, H.F. (1990. X chromosome inactivation of the human TIMP gene. Nucleic Acids Res. 18,4191–4195.

    Article  PubMed  CAS  Google Scholar 

  • Brown, C.J., Ballabio, A., Rupert, J.L., Lafreniere, R.G., Grompe, M., Tonlorenzi, R., Willard, H.F. (1991). A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349, 38–44.

    Article  PubMed  CAS  Google Scholar 

  • Brown, S.D.M., Avner, P., Boyd, Y., Chapman, V., Rastan, S., Sefton, L., Thomas, J.D., Herman, G.E. (1993). Mouse X chromosome. Mamm. Genome 4(Suppl.), S269-S281.

    CAS  Google Scholar 

  • Davies, K.E., Mandel, J.L., Monaco, A.P., Nussbaum, R.L., Willard, H.F. (1992). Report of the committee on the genetic constitution of the X chromosome. Cytogenet. Cell Genet. 58, 1–117.

    Article  Google Scholar 

  • Dietrich, A., Korn, B., Poutska, A. (1992). Completion of the physical map of Xq28: the location of the gene for LI CAM on the human X chromosome. Mamm. Genome 3, 168–172.

    CAS  Google Scholar 

  • Kaneko, K., Warren, S.T., Miyatake, T., Tsuji, S. (1993) Isolation of 353 Not I linking clones and 62 DNA markers (DXS607-DXS668) from human chromosome Xq24-qter. Cytogenet. Cell Genet. 64, 5–8.

    Article  PubMed  CAS  Google Scholar 

  • Levinson, B., Kenwrick, S., Lakich, D., Hammonds, G., Gitschier, J. (1990). A transcribed gene in an intron of the human factor VIII gene. Genomics 7, 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Levinson, B., Bermingham, J.R., Metzenberg, A., Kenwrick, S., Chapman, V., Gitschier, J. (1992). Sequence of the factor VIII-associated gene is conserved in mouse. Genomics 13, 862–865.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, J.D., Meehan, R.R., Henzel, W.J., Maurer-Fogy, I., Jeppesen, P., Klein, F., Bird, A.P. (1992). Purification, sequence and cellular localisation of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905–914.

    Article  PubMed  CAS  Google Scholar 

  • Li, E., Bester, T.H., Jaenisch, R. (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926.

    Article  PubMed  CAS  Google Scholar 

  • Meehan, R.R., Lewis, J.D., McKay, S., Kleiner, E.L., Bird, A.P. (1989). Identification of a mammalian protein that binds specifically to DNA that contains methylated CpGs. Cell 58, 499–507.

    Article  PubMed  CAS  Google Scholar 

  • Meehan, R.R., Lewis, J.D., Bird, A.P. (1992a). Characterisation of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA. Nucleic Acids Res. 20, 5085–5092.

    Article  PubMed  CAS  Google Scholar 

  • Meehan, R.R., Lewis, J.D., Cross, S.H., Nan, X., Jeppesen, P., Bird, A.P. (1992b). Transcriptional repression by methylation of CpG. J. Cell sci. 16, 9–14.

    CAS  Google Scholar 

  • Nan, X., Meehan, R.R., Bird, A.P. (1993). Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nucleic Acids Res. 21, 4886–4892.

    Article  PubMed  CAS  Google Scholar 

  • Palmieri, G., Romano, G., Ciccodicola, A., Casamassimi, A., Campanile, C, Esposito, T., Cappa, V., Lania, A., Johnson, S., Reinbold, R., Poutska, A., Schlessinger, D., D’;Urso, M. (1994). YAC contig organisation and CpG island analysis in Xq28. Genomics 24, 149–158.

    Article  PubMed  CAS  Google Scholar 

  • Quaderi, N.A., Meehan, R.R., Tate, P.H., Cross, S.H., Bird, A.P., Chatterjee, A., Herman, G.E., Brown, S.D.M. (1994). Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome. Genomics 22, 648–651.

    Article  PubMed  CAS  Google Scholar 

  • Tate, P., Skarnes, W., Bird, A. (1996). The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Nature Genet. 12, 205–208.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

D’Esposito, M., Quaderi, N.A., Ciccodicola, A. et al. Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2. Mammalian Genome 7, 533–535 (1996). https://doi.org/10.1007/s003359900157

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s003359900157

Keywords

Navigation