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Genetic mapping of the autosomal region involved in XX sex-reversal and horn development in goats

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Abstract

Contrary to other genetic disorders, the genetic study of sex determination anomalies in humans stumbles over the difficulty in observing large pedigrees. In goats, abnormalities in sex determination are intimately linked to a dominant Mendelian gene coding for the “polled” (hornless) character, which could render this species an interesting animal model for the rare human cases of SRY-negative XX males. In this report, we describe genetic linkage between the polled/intersex synchome (PIS) and four microsatellite markers of the distal region of goat Chromosome 1 (CHI1), quite distinct from the bovine “polled” region. According to comparative mapping data, no sex-determining gene has been described so far in homologous regions in the human. This genetic localization constitutes a first step towards identifying a new autosomal sex-determining gene in mammals.

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Authors and Affiliations

  1. Departement de Génétique Animale, Laboratoire de Génétique biochimique et de Cytogénétique, Centre de Recherches de Jouy-en-Josas, Institut National de la Recherche Agronomique, 78352, Jouy-en-Josas, France

    D. Vaiman, A. Oustry & E. P. Cribiu

  2. Department of Animal Production, Aristotle University of Thessaloniki, GR-540-06, Thessaloniki, Greece

    O. Koutita

  3. Institut National de la Recherche Agronomique, Departement de Génétique Animale, Station d’Amélioration et de Génétique Animale, Centre de Recherches de Toulouse, 31326, Castanet Tolosan Cedex, France

    J. -M. Elsen & E. Manfredi

  4. Institut Pasteur, Laboratoire d’Immunogénétique Humaine, Institut National de la Santé et de la Recherche Médicale U.276, I25-28 rue du Dr Roux, 75724, Paris, Cedex 15, France

    M. Fellous

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  1. D. Vaiman
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  2. O. Koutita
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  3. A. Oustry
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  4. J. -M. Elsen
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  7. E. P. Cribiu
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Vaiman, D., Koutita, O., Oustry, A. et al. Genetic mapping of the autosomal region involved in XX sex-reversal and horn development in goats. Mammalian Genome 7, 133–137 (1996). https://doi.org/10.1007/s003359900033

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  • DOI: https://doi.org/10.1007/s003359900033

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