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Identification of immunological relevant phenotypes in ENU mutagenized mice

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Abstract.

The immunology screen focuses on the identification of novel gene products involved in the mammalian immune response and on the establishment of mouse models for immunological disorders. For this purpose, high throughput and semi-automated techniques were developed and optimized for low cost per sample and reproducibility. All assays are designed to be nonconsumptive and are based on peripheral blood or direct PCR amplification.

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Authors and Affiliations

  1. Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Troger Straße 4a, 81675 München, Germany, DE

    Heinrich Flaswinkel, Angela Servatius & Klaus Pfeffer

  2. Division of Environmental Dermatology and Allergology, Technische Universität München/GSF Research Center for Environment and Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, DE

    Francesca Alessandrini, Thilo Jakob & Heidrun Behrendt

  3. Institute of Molecular Animal Breeding, Gene Center, Feodor-Lynen-Str. 25, 81377 München, Germany, DE

    Birgit Rathkolb, Tanja Decker & Eckhard Wolf

  4. Institute of Molecular Immunology GSF Research Center for Environment and Health Marchionistr. 25, 81377 München, Germany, DE

    Elisabeth Kremmer & Johannes Ring

  5. Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, DE

    Dian Soewarto, Susan Marschall, Christiane Fella, Rudi Balling & Martin Hrabé de Angelis

Authors
  1. Heinrich Flaswinkel
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  2. Francesca Alessandrini
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  3. Birgit Rathkolb
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  4. Tanja Decker
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  5. Elisabeth Kremmer
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  6. Angela Servatius
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  7. Thilo Jakob
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  8. Dian Soewarto
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  9. Susan Marschall
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  10. Christiane Fella
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  11. Heidrun Behrendt
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  12. Johannes Ring
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  13. Eckhard Wolf
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  14. Rudi Balling
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  15. Martin Hrabé de Angelis
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  16. Klaus Pfeffer
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Additional information

Received: 16 December 1999 / Accepted: 16 December 1999

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Flaswinkel, H., Alessandrini, F., Rathkolb, B. et al. Identification of immunological relevant phenotypes in ENU mutagenized mice. Mammalian Genome 11, 526–527 (2000). https://doi.org/10.1007/s003350010100

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  • DOI: https://doi.org/10.1007/s003350010100

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