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Promises and challenges of cardiac organoids

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Abstract

Cardiovascular diseases are currently the main cause of death. The study of the pathogenesis and treatment of these diseases is still a major challenge. Traditional 2D cultured cells and animal models have certain limitations. Heart organoids as models can simulate the structure and function of the body, providing a new research strategy. This paper mainly discusses the development of organoids and their application in the study of the cardiac developmental process, drug screening and treatment of genetic and non-genetic diseases, concluding with their strengths and weaknesses.

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Funding

This study was supported by the National Key R&D Program of China (2022YFA1104300, 2021YFA1101902), the National Natural Science Foundation of China (82241202, 82170364, 81970223, 82000263), the Natural Science Foundation of Jiangsu Province (BK20201409), Jiangsu Cardiovascular Medicine Innovation Center (CXZX202210).

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Author notes

  1. Jingxian Li, Jingsi Yang are Co-first authors.

Authors and Affiliations

  1. Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, 215000, China

    Jingxian Li, Jingsi Yang, Dandan Zhao, Wei Lei & Shijun Hu

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  1. Jingxian Li
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  2. Jingsi Yang
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  3. Dandan Zhao
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  4. Wei Lei
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  5. Shijun Hu
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JL, JY, DZ, WL and SH: wrote and revised the manuscript. All authors read, edited and approved the manuscript.

Corresponding authors

Correspondence to Wei Lei or Shijun Hu.

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Li, J., Yang, J., Zhao, D. et al. Promises and challenges of cardiac organoids. Mamm Genome 34, 351–356 (2023). https://doi.org/10.1007/s00335-023-09987-y

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  • DOI: https://doi.org/10.1007/s00335-023-09987-y

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