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Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei


Malaria is a common and sometimes fatal disease caused by infection with Plasmodium parasites. Cerebral malaria (CM) is a most severe complication of infection with Plasmodium falciparum parasites which features a complex immunopathology that includes a prominent neuroinflammation. The experimental mouse model of cerebral malaria (ECM) induced by infection with Plasmodium berghei ANKA has been used abundantly to study the role of single genes, proteins and pathways in the pathogenesis of CM, including a possible contribution to neuroinflammation. In this review, we discuss the Plasmodium berghei ANKA infection model to study human CM, and we provide a summary of all host genetic effects (mapped loci, single genes) whose role in CM pathogenesis has been assessed in this model. Taken together, the reviewed studies document the many aspects of the immune system that are required for pathological inflammation in ECM, but also identify novel avenues for potential therapeutic intervention in CM and in diseases which feature neuroinflammation.

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The work in PG lab was supported by grants to PG from the Canadian Institutes of Health Research, and the Canadian Institute for Advanced Research. PG is endebted to the many trainees in his lab that have contributed to the genetic analysis of susceptibility to malaria in mouse models of infection.

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Torre, S., Langlais, D. & Gros, P. Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei. Mamm Genome 29, 488–506 (2018). https://doi.org/10.1007/s00335-018-9752-9

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