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Enterobacteria and host resistance to infection


Enterobacteriaceae are a large family of Gram-negative, non-spore-forming bacteria. Although many species exist as part of the natural flora of animals including humans, some members are associated with both intestinal and extraintestinal diseases. In this review, we focus on members of this family that have important roles in human disease: Salmonella, Escherichia, Shigella, and Yersinia, providing a brief overview of the disease caused by these bacteria, highlighting the contribution of animal models to our understanding of their pathogenesis and of host genetic determinants involved in susceptibility or resistance to infection.

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L.C. and X.M. are grateful to Christian Demeure for useful discussions on Y. pestis pathogenesis and mouse models. Funding for this work was supported by the Canadian Institutes of Health Research grants to S.G. (Grant No. MOP 133580) and to D.M. (Grant No. MOP133700); by Genome Canada and Génome Québec to S.G. and D.M.; by the National Science and Engineering Research Council of Canada (NSERC, Grant No. RGPIN-2016-05587) and the Faculty of Science of the University of Ottawa to F.X.C.V. E.K. was supported by studentships from the Faculty of Medicine, McGill University; A.A. by a scholarship from the King Abdullah Scholarship program supported by the Saudi Arabia Cultural Bureau and N.S. by a studentship from the NSERC CREATE program TECHNOMISE.

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Kang, E., Crouse, A., Chevallier, L. et al. Enterobacteria and host resistance to infection. Mamm Genome 29, 558–576 (2018). https://doi.org/10.1007/s00335-018-9749-4

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