Skip to main content

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

Abstract

Determining the function of all mammalian genes remains a major challenge for the biomedical science community in the 21st century. The goal of the International Mouse Phenotyping Consortium (IMPC) over the next 10 years is to undertake broad-based phenotyping of 20,000 mouse genes, providing an unprecedented insight into mammalian gene function. This short article explores the drivers for large-scale mouse phenotyping and provides an overview of the aims and processes involved in IMPC mouse production and phenotyping.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  • Ayadi A, Birling M, Bottomley J, Bussell J, Fuchs H et al (2012) Mouse large-scale phenotyping initiatives: Overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetic Project. Mamm Genome. doi:10.1007/s00335-012-9418-y

    Google Scholar 

  • Brown SD, Chambon P, de Angelis MH (2005) EMPReSS: standardized phenotype screens for functional annotation of the mouse genome. Nat Genet 37:1155

    PubMed  Article  CAS  Google Scholar 

  • Brown SD, Hancock JM, Gates H (2006) Understanding mammalian genetic systems: the challenge of phenotyping in the mouse. PLoS Genet 2:e118

    PubMed  Article  Google Scholar 

  • Brown SD, Wurst W, Kuhn R, Hancock JM (2009) The functional annotation of mammalian genomes: the challenge of phenotyping. Ann Rev Genet 43:305–333

    PubMed  Article  CAS  Google Scholar 

  • Copp A (1995) Death before birth: clues from gene knockouts and mutations. Trends Genet 11:87–93

    PubMed  Article  CAS  Google Scholar 

  • Eppig JT, Blake JA, Bult CJ, Kadin JA, Richardson JE (2012) The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res 40:D881–D886

    PubMed  Article  CAS  Google Scholar 

  • Gailus-Durner V et al (2005) Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods 2:403–404

    PubMed  Article  CAS  Google Scholar 

  • Hoehndorf R, Schofield PN, Gkoutos GV (2011) PhenomeNET: a whole phenome approach to disease gene discovery. Nucleic Acids Res 39:e119

    PubMed  Article  CAS  Google Scholar 

  • Larina IV et al (2012) Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models. J Biomed Opt 17:081410

    Article  Google Scholar 

  • Mallon AM, Blake A, Hancock JM (2008) EuroPhenome and EMPReSS: online mouse phenotyping resource. Nucleic Acids Res 36:D715–D718

    PubMed  Article  CAS  Google Scholar 

  • Mallon AM, Iyer V, Melvin D, Morgan H, Parkinson H et al (2012) Accessing data from the International Mouse Phenotyping Consortium, state of the art and future plans. Mamm Genome. doi:10.1007/s00335-012-9428-9

    Google Scholar 

  • Metscher BD (2009) MicroCT for comparative morphology: simple staining methods allow high-contrast 3D imaging of diverse non-mineralized animal tissues. BMC Physiol 9:11–25

    PubMed  Article  Google Scholar 

  • Morgan H et al (2010) EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res 38:D577–D585

    PubMed  Article  CAS  Google Scholar 

  • Schofield PN, Vogel P, Gkoutos GV, Sundberg JP (2012) Exploring the elephant: histopathology in the high-throughput phenotyping of mutant mice. Dis Model Mech 5:19–25

    PubMed  Article  CAS  Google Scholar 

  • Sharpe J et al (2002) Optical projection tomography as a tool for 3D microscopy and gene expression studies. Science 296:541–545

    PubMed  Article  CAS  Google Scholar 

  • Skarnes WC et al (2011) A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474:337–342

    PubMed  Article  CAS  Google Scholar 

  • Weninger WJ et al (2006) High-resolution episcopic microscopy: a rapid technology for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology. Anat Embryol 211:213–221

    PubMed  Article  Google Scholar 

  • Zamyadi M, Baghdadi L, Lerch JP, Bhattacharya S, Schneider JE et al (2010) Mouse embryonic phenotyping by morphometric analysis of MR images. Physiol Genomics 42:89–95

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steve D. M. Brown.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Brown, S.D.M., Moore, M.W. The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping. Mamm Genome 23, 632–640 (2012). https://doi.org/10.1007/s00335-012-9427-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00335-012-9427-x

Keywords

  • Phenotype Ontology
  • Wellcome Trust Sanger Institute
  • Phenotype Annotation
  • Mandatory Test
  • Data Coordination Centre