Skip to main content

How host defense is encoded in the mammalian genome

Abstract

This issue of Mammalian Genome explores the genetic approach to infectious disease susceptibility as it has been applied in mammals. Although no single issue of any journal could give comprehensive treatment to a field so extensive and rapidly growing as this one, these texts describe key discoveries that provided new understanding of immune responses. Classical genetic studies opened and continue to pave the way to deep understanding of many issues in immunology.

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. Beutler BA (2009) TLRs and innate immunity. Blood 113:1399–1407

    CAS  Article  PubMed  Google Scholar 

  2. Blasius AL, Beutler B (2010) Intracellular toll-like receptors. Immunity 32:305–315

    CAS  Article  PubMed  Google Scholar 

  3. Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB et al (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 27:68–73

    CAS  Article  PubMed  Google Scholar 

  4. Cohen PL, Eisenberg RA (1991) Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol 9:243–269

    CAS  Article  PubMed  Google Scholar 

  5. Crozat K, Hoebe K, Ugolini S, Hong NA, Janssen E et al (2007) Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med 204:853–863

    CAS  Article  PubMed  Google Scholar 

  6. Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB et al (2008) Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med 5:e54

    Article  PubMed  Google Scholar 

  7. Hunn JP, Feng CG, Sher A, Howard JC (this issue) The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mamm Genome 22: doi:10.1007/s00335-010-9293-3

  8. Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373–384

    CAS  Article  PubMed  Google Scholar 

  9. Krebs P, Barnes MJ, Lampe K, Whitley K, Bahjat KS et al (2009) NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses. Blood 113:6593–6602

    CAS  Article  PubMed  Google Scholar 

  10. Liston A, Lesage S, Gray DH, Boyd RL, Goodnow CC (2005) Genetic lesions in T-cell tolerance and thresholds for autoimmunity. Immunol Rev 204:87–101

    CAS  Article  PubMed  Google Scholar 

  11. Longley R, Smith C, Fortan A, Berghout J, McMorran B, Burgio G, Foote S, Gros P (this issue) Host resistance to malaria: using mouse models to explore the host response. Mamm Genome 22. doi:10.1007/s00335-010-9302-6

  12. Marakalala MJ, Kerrigan AM, Brown GD (2011) Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. Mamm Genome 22. doi:10.1007/s00335-010-9277-3

  13. Morens DM, Folkers GK, Fauci AS (2004) The challenge of emerging and re-emerging infectious diseases. Nature 430:242–249

    CAS  Article  PubMed  Google Scholar 

  14. Pancer Z, Amemiya CT, Ehrhardt GR, Ceitlin J, Gartland GL et al (2004) Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature 430:174–180

    CAS  Article  PubMed  Google Scholar 

  15. Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB et al (2006) Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 312:1669–1672

    CAS  Article  PubMed  Google Scholar 

  16. Poltorak A, He X, Smirnova I, Liu M, Van Huffel C et al (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085–2088

    CAS  Article  PubMed  Google Scholar 

  17. Pyzik M, Gendron-Pontbriand EM, Fodil-Cornu N, Vidal SM (2011) Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors. Mamm Genome 22. doi:10.1007/s00335-010-9286-2

  18. Raulet DH (2006) Missing self recognition and self tolerance of natural killer (NK) cells. Semin Immunol 18:145–150

    CAS  Article  PubMed  Google Scholar 

  19. Ronald PC, Beutler B (2010) Plant and animal sensors of conserved microbial signatures. Science 330:1061–1064

    CAS  Article  PubMed  Google Scholar 

  20. Ryan JG, Kastner DL (2008) Fevers, genes, and innate immunity. Curr Top Microbiol Immunol 321:169–184

    CAS  Article  PubMed  Google Scholar 

  21. Subramanian S, Tus K, Li QZ, Wang A, Tian XH et al (2006) A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA 103:9970–9975

    CAS  Article  PubMed  Google Scholar 

  22. Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L et al (2005) A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435:452–458

    CAS  Article  PubMed  Google Scholar 

  23. Wilmoth JR (2000) Demography of longevity: past, present, and future trends. Exp Gerontol 35:1111–1129

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Bruce Beutler or Christopher C. Goodnow.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Beutler, B., Goodnow, C.C. How host defense is encoded in the mammalian genome. Mamm Genome 22, 1–5 (2011). https://doi.org/10.1007/s00335-010-9312-4

Download citation

Keywords

  • Natural Killer Cell
  • Innate Immune System
  • Host Resistance
  • Selective Sweep
  • Autoinflammatory Disease