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How host defense is encoded in the mammalian genome


This issue of Mammalian Genome explores the genetic approach to infectious disease susceptibility as it has been applied in mammals. Although no single issue of any journal could give comprehensive treatment to a field so extensive and rapidly growing as this one, these texts describe key discoveries that provided new understanding of immune responses. Classical genetic studies opened and continue to pave the way to deep understanding of many issues in immunology.

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Correspondence to Bruce Beutler or Christopher C. Goodnow.

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Beutler, B., Goodnow, C.C. How host defense is encoded in the mammalian genome. Mamm Genome 22, 1–5 (2011).

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  • Natural Killer Cell
  • Innate Immune System
  • Host Resistance
  • Selective Sweep
  • Autoinflammatory Disease