References
Amaral PP, Mattick JS (2008) Noncoding RNA in development. Mamm Genome. doi:10.1007/s00335-008-9136-7
Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113:673–676
Ashraf SI, Kunes S (2006) A trace of silence: memory and microRNA at the synapse. Curr Opin Neurobiol 16:535–539
Avner P, Heard E (2001) X-chromosome inactivation, counting, choice and initiation. Nat Rev Genet 2:59–67
Barbato C, Giorgi C, Catalanotto C, Cogoni C (2008) Thinking about RNA? MicroRNAs in the brain. Mamm Genome. doi:10.1007/s00335-008-9129-6
Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297
Berezikov E, Thuemmler F, van Laake LW, Kondova I, Bontrop R et al (2006) Diversity of microRNAs in human and chimpanzee brain. Nat Genet 38:1375–1377
Borel C, Antonarakis SE (2008) Functional genetic variation of human miRNAs and phenotypic consequences. Mamm Genome. doi:10.1007/s00335-008-9137-6
Brannan CI, Dees EC, Ingram RS, Tilghman SM (1990) The product of the H19 gene may function as an RNA. Mol Cell Biol 10:28–36
Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S et al (2002) Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99:15524–15529
Carthew RW (2006) Gene regulation by microRNAs. Curr Opin Genet Dev 16:203–208
Cullen BR (2004) Transcription and processing of human microRNA precursors. Mol Cell 16:861–865
Fabbri M, Croce CM, Calin GA (2008) MicroRNAs. Cancer J 14:1–6
Furuno M, Pang KC, Ninomiya N, Fukuda S, Frith MC et al (2006) Clusters of internally primed transcripts reveal novel long noncoding RNAs. PLoS Genet 2:e37
Gregory RI, Yan KP, Amuthan G, Chendrimada TP, Doratotaj B et al (2004) The microprocessor complex mediates the genesis of microRNAs. Nature 432:235–240
He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5:522–531
He S, Su H, Liu C, Skogerbo G, He H et al (2008) MicroRNA-encoding long non-coding RNAs. BMC Genomics 9:236
Huang KM, Dentchev T, Stambolian D (2008) MiRNA expression in the eye. Mamm Genome. doi:10.1007/s00335-008-9127-8
Lee CT, Risom T, Strauss WM (2007) Evolutionary conservation of microRNA regulatory circuits: an examination of microRNA gene complexity and conserved microRNA-target interactions through metazoan phylogeny. DNA Cell Biol 26:209–218
Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854
Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates thousands of human genes are microRNA targets. Cell 120:15–20
Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM et al (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433:769–773
Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J et al (2005) MicroRNA expression profiles classify human cancers. Nature 435:834–838
Mattick JS (2005) The functional genomics of noncoding RNA. Science 309:1527–1528
Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL et al (2006) A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 126:1203–1217
Parsons MJ, Grimm CH, Paya-Cano JL, Sugden K, Nietfeld W et al (2008) Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mamm Genome. doi:10.1007/s00335-008-9116-y
Peters J, Robson JE (2008) Imprinted noncoding RNAs. Mamm Genome. doi:10.1007/s00335-008-9139-4
Prasanth KV, Spector DL (2008) Eukaryotic regulatory RNAs: an answer to the ‘genome complexity’ conundrum. Genes Dev 21:11–42
Presutti C, Rosati J, Vincenti S, Nasi S (2006) Noncoding RNA and brain. BMC Neurosci 7(Suppl 1):S5
Rigoutsos I, Huynh T, Miranda K, Tsirigos A, McHardy A et al (2006) Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes. Proc Natl Acad Sci USA 103:6605–6610
Rossi S, Sevignani C, Siracusa LD, Calin G (2008) Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. Mamm Genome. doi:10.1007/s00335-008-9119-8
Rouhi A, Mager DL, Humphries RK, Kuchenbauer F (2008) MiRNAs, epigenetics, and cancer. Mamm Genome. doi:10.1007/s00335-008-9133-x
Sevignani C, Calin GA, Nnadi SC, Shimizu M, Davuluri RV et al (2007) MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci USA 104:8017–8022
Sleutels F, Zwart R, Barlow DP (2002) The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature 415:810–813
Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A et al (2006) microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257–2261
Yasuda J, Hayashizaki Y (2008) The RNA continent. Adv Cancer Res 99:77–112
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Siracusa, L.D., Buchberg, A.M. The noncoding RNAs: a genomic symphony of transcripts. Mamm Genome 19, 449–453 (2008). https://doi.org/10.1007/s00335-008-9151-8
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DOI: https://doi.org/10.1007/s00335-008-9151-8