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The noncoding RNAs: a genomic symphony of transcripts

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References

  • Amaral PP, Mattick JS (2008) Noncoding RNA in development. Mamm Genome. doi:10.1007/s00335-008-9136-7

  • Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113:673–676

    Article  CAS  Google Scholar 

  • Ashraf SI, Kunes S (2006) A trace of silence: memory and microRNA at the synapse. Curr Opin Neurobiol 16:535–539

    Article  CAS  Google Scholar 

  • Avner P, Heard E (2001) X-chromosome inactivation, counting, choice and initiation. Nat Rev Genet 2:59–67

    Article  CAS  Google Scholar 

  • Barbato C, Giorgi C, Catalanotto C, Cogoni C (2008) Thinking about RNA? MicroRNAs in the brain. Mamm Genome. doi:10.1007/s00335-008-9129-6

  • Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297

    Article  CAS  Google Scholar 

  • Berezikov E, Thuemmler F, van Laake LW, Kondova I, Bontrop R et al (2006) Diversity of microRNAs in human and chimpanzee brain. Nat Genet 38:1375–1377

    Article  CAS  Google Scholar 

  • Borel C, Antonarakis SE (2008) Functional genetic variation of human miRNAs and phenotypic consequences. Mamm Genome. doi:10.1007/s00335-008-9137-6

  • Brannan CI, Dees EC, Ingram RS, Tilghman SM (1990) The product of the H19 gene may function as an RNA. Mol Cell Biol 10:28–36

    CAS  PubMed  PubMed Central  Google Scholar 

  • Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S et al (2002) Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99:15524–15529

    Article  CAS  Google Scholar 

  • Carthew RW (2006) Gene regulation by microRNAs. Curr Opin Genet Dev 16:203–208

    Article  CAS  Google Scholar 

  • Cullen BR (2004) Transcription and processing of human microRNA precursors. Mol Cell 16:861–865

    Article  CAS  Google Scholar 

  • Fabbri M, Croce CM, Calin GA (2008) MicroRNAs. Cancer J 14:1–6

    Article  CAS  Google Scholar 

  • Furuno M, Pang KC, Ninomiya N, Fukuda S, Frith MC et al (2006) Clusters of internally primed transcripts reveal novel long noncoding RNAs. PLoS Genet 2:e37

    Article  Google Scholar 

  • Gregory RI, Yan KP, Amuthan G, Chendrimada TP, Doratotaj B et al (2004) The microprocessor complex mediates the genesis of microRNAs. Nature 432:235–240

    Article  CAS  Google Scholar 

  • He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5:522–531

    Article  CAS  Google Scholar 

  • He S, Su H, Liu C, Skogerbo G, He H et al (2008) MicroRNA-encoding long non-coding RNAs. BMC Genomics 9:236

    Article  Google Scholar 

  • Huang KM, Dentchev T, Stambolian D (2008) MiRNA expression in the eye. Mamm Genome. doi:10.1007/s00335-008-9127-8

  • Lee CT, Risom T, Strauss WM (2007) Evolutionary conservation of microRNA regulatory circuits: an examination of microRNA gene complexity and conserved microRNA-target interactions through metazoan phylogeny. DNA Cell Biol 26:209–218

    Article  CAS  Google Scholar 

  • Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854

    Article  CAS  Google Scholar 

  • Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates thousands of human genes are microRNA targets. Cell 120:15–20

    Article  CAS  Google Scholar 

  • Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM et al (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433:769–773

    Article  CAS  Google Scholar 

  • Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J et al (2005) MicroRNA expression profiles classify human cancers. Nature 435:834–838

    Article  CAS  Google Scholar 

  • Mattick JS (2005) The functional genomics of noncoding RNA. Science 309:1527–1528

    Article  CAS  Google Scholar 

  • Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL et al (2006) A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 126:1203–1217

    Article  CAS  Google Scholar 

  • Parsons MJ, Grimm CH, Paya-Cano JL, Sugden K, Nietfeld W et al (2008) Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mamm Genome. doi:10.1007/s00335-008-9116-y

  • Peters J, Robson JE (2008) Imprinted noncoding RNAs. Mamm Genome. doi:10.1007/s00335-008-9139-4

  • Prasanth KV, Spector DL (2008) Eukaryotic regulatory RNAs: an answer to the ‘genome complexity’ conundrum. Genes Dev 21:11–42

    Article  Google Scholar 

  • Presutti C, Rosati J, Vincenti S, Nasi S (2006) Noncoding RNA and brain. BMC Neurosci 7(Suppl 1):S5

    Article  Google Scholar 

  • Rigoutsos I, Huynh T, Miranda K, Tsirigos A, McHardy A et al (2006) Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes. Proc Natl Acad Sci USA 103:6605–6610

    Article  CAS  Google Scholar 

  • Rossi S, Sevignani C, Siracusa LD, Calin G (2008) Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. Mamm Genome. doi:10.1007/s00335-008-9119-8

  • Rouhi A, Mager DL, Humphries RK, Kuchenbauer F (2008) MiRNAs, epigenetics, and cancer. Mamm Genome. doi:10.1007/s00335-008-9133-x

  • Sevignani C, Calin GA, Nnadi SC, Shimizu M, Davuluri RV et al (2007) MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci USA 104:8017–8022

    Article  CAS  Google Scholar 

  • Sleutels F, Zwart R, Barlow DP (2002) The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature 415:810–813

    Article  CAS  Google Scholar 

  • Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A et al (2006) microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257–2261

    Article  CAS  Google Scholar 

  • Yasuda J, Hayashizaki Y (2008) The RNA continent. Adv Cancer Res 99:77–112

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA, 19107-5541, USA

    Linda D. Siracusa & Arthur M. Buchberg

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  1. Linda D. Siracusa
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  2. Arthur M. Buchberg
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Correspondence to Linda D. Siracusa.

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Siracusa, L.D., Buchberg, A.M. The noncoding RNAs: a genomic symphony of transcripts. Mamm Genome 19, 449–453 (2008). https://doi.org/10.1007/s00335-008-9151-8

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