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The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort

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Abstract

We report on the progress of a project funded by the Wellcome Trust to produce over 100 recombinant inbred mouse lines as part of the Collaborative Cross (CC) genetic reference panel. These new strains of mice are being derived from a set of eight genetically diverse founders. The genomes of the finished strains will be mosaics of the founder strains’ genomes with a high density of independent recombination breakpoints. The CC mice will be available for distribution free of any intellectual property constraints to serve as a community resource for systems genetics studies.

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Acknowledgments

The authors appreciate the generous support of Wellcome Trust for funding this project, and the International Livestock Research Institute (ILRI) and Tel Aviv University for their technical support.

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Authors and Affiliations

  1. Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel

    Fuad A. Iraqi

  2. The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA

    Gary Churchill

  3. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Richard Mott

Authors
  1. Fuad A. Iraqi
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  2. Gary Churchill
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  3. Richard Mott
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Correspondence to Fuad A. Iraqi.

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Iraqi, F.A., Churchill, G. & Mott, R. The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust cohort. Mamm Genome 19, 379–381 (2008). https://doi.org/10.1007/s00335-008-9113-1

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  • DOI: https://doi.org/10.1007/s00335-008-9113-1

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