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Mammalian Genome

, Volume 16, Issue 4, pp 262–272 | Cite as

Association of an Agouti allele with fawn or sable coat color in domestic dogs

  • Tom G. Berryere
  • Julie A. Kerns
  • Gregory S. Barsh
  • Sheila M. Schmutz
Article

Abstract

The type of pigment synthesized in mammalian hair, yellow–red pheomelanin or black–brown eumelanin, depends on the interaction between Agouti protein and the Melanocortin 1 receptor. Although the genetics of pigmentation is broadly conserved across most mammalian species, pigment type-switching in domestic dogs is unusual because a yellow–tan coat with variable amounts of dark hair is thought to be caused by an allele of the Agouti locus referred to as fawn or sable (a y ). In a large survey covering thirty seven breeds, we identified an Agouti allele with two missense alterations, A82S and R83H, which was present (heterozygous or homozygous) in 41 dogs (22 breeds) with a fawn or sable coat, but was absent from 16 dogs (8 breeds) with a black-and-tan or tricolor phenotype. In an additional 33 dogs (14 breeds) with a eumelanic coat, 8 (German Shepherd Dogs, Groenendaels, Schipperkes, or Shetland Sheepdogs) were homozygous for a previously reported mutation, non-agouti R96C; the remainder are likely to have carried dominant black, which is independent of and epistatic to Agouti. This work resolves some of the complexity in dog coat color genetics and provides diagnostic opportunities and practical guidelines for breeders.

Keywords

Coat Color Black Hair Doberman Pinscher Agouti Protein Coat Color Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank the Natural Science and Engineering Research Council for funding. We are grateful to Ingeborg Roewer for careful and patient sequencing. We especially thank Libbye Miller and Lee Jiles, Marla Belzowski and Jackie Barikhan, C.A. Sharp, J. P. Yousha, Sue Ann Bowling, and the many dog owners who helped us obtain DNA samples. We thank Solomon Carriere for coyote and wolf skin samples.

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Copyright information

© Springer Science+Business Media Inc. 2005

Authors and Affiliations

  • Tom G. Berryere
    • 1
  • Julie A. Kerns
    • 2
  • Gregory S. Barsh
    • 2
  • Sheila M. Schmutz
    • 1
  1. 1.Department of Animal and Poultry ScienceUniversity of SaskatchewanSaskatoonCanada
  2. 2.Departments of Genetics and PediatricsStanford University School of MedicineStanfordUSA

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