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Characterization of a centromeric marker on mouse Chromosome 11 and its introgression in a domesticus/musculus hybrid zone

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Abstract

It has been proposed that the distribution of Robertsonian chromosome fusions and the Chromosome 11 Nucleolar Organizer Region (NOR) in the Danish hybrid zone between M. m. musculus and M. m. domesticus stems from centromeric incompatibilities between the two subspecies. To test this hypothesis, we identified and characterized a diagnostic subspecific marker closely linked to the centromere on mouse Chromosome 11. Using an allele-specific PCR assay, we investigated the introgression pattern of this centromere in a large sample of mice from a North–South transect of the hybrid zone in Jutland. Domesticus alleles were found to introgress far away from the center of the zone on the musculus side. These results suggest there is no incompatibility between the domesticus centromere of Chromosome 11 in the musculus genomic background.

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References

  • Barton N, Baird S (1998) Analyse, a tool for the population genetic analysis of geographic variation and hybrid zones. http://helios.bto.ed.ac.uk/evolgen/Mac/Analyse/

  • J Britton–Davidian J Catalan M da Graca Ramalhinho G Ganem JC Auffray et al. (2000) ArticleTitleRapid chromosomal evolution in island mice Nature 403 IssueID6766 158 Occurrence Handle10.1038/35003116 Occurrence Handle1:CAS:528:DC%2BD3cXms1Wjsg%3D%3D Occurrence Handle10646592

    Article  CAS  PubMed  Google Scholar 

  • M Clamp D Andrews D Barker P Bevan G Cameron (2003) ArticleTitleEnsembl 2002: accommodating comparative genomics Nucleic Acids Res 31 IssueID1 38–42 Occurrence Handle10.1093/nar/gkg083 Occurrence Handle1:CAS:528:DC%2BD3sXhvFSgu7o%3D Occurrence Handle12519943

    Article  CAS  PubMed  Google Scholar 

  • GP Copenhaver D Preuss (1999) ArticleTitleCentromeres in the genomic era: unraveling paradoxes Curr Opin Plant Biol 2 IssueID2 104–108 Occurrence Handle10.1016/S1369-5266(99)80021-1 Occurrence Handle1:CAS:528:DyaK1MXivVGlsL4%3D Occurrence Handle10322201

    Article  CAS  PubMed  Google Scholar 

  • E Desmarais I Lanneluc J Lagnel (1998) ArticleTitleDirect amplification of length polymorphisms (DALP), or how to get and characterize new genetic markers in many species Nucleic Acids Res 26 IssueID6 1458–1465 Occurrence Handle10.1093/nar/26.6.1458 Occurrence Handle1:CAS:528:DyaK1cXit1Gisrw%3D Occurrence Handle9490792

    Article  CAS  PubMed  Google Scholar 

  • B Dod LS Jermiin P Boursot VH Chapman JT Nielsen et al. (1993) ArticleTitleCounterselection on sex chromosomes in the Mus musculus European hybrid zone J Evol Biol 6 IssueID4 529–546

    Google Scholar 

  • B Dod C Smadja RC Karn P Boursot (in press) ArticleTitleTesting for selection on the Androgen-Binding Protein in the Danish mouse hybrid zone Biol J Linn Soc (special volume) . .

    Google Scholar 

  • D du Sart MR Cancilla E Earle JI Mao R Saffery et al. (1997) ArticleTitleA functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA Nat Genet 16 IssueID2 144–153 Occurrence Handle10.1038/ng0697-144 Occurrence Handle1:CAS:528:DyaK2sXjs1aiurc%3D Occurrence Handle9171825

    Article  CAS  PubMed  Google Scholar 

  • F Fel-Clair J Catalan T Lenormand J Britton–Davidian (1998) ArticleTitleCentromeric incompatibilities in the hybrid zone between house mouse subspecies from Denmark: evidence from patterns of NOR activity Evolution 52 IssueID2 592–603

    Google Scholar 

  • S Garagna D Broccoli CA Redi JB Searle HJ Cooke et al. (1995) ArticleTitleRobertsonian metacentrics of the house mouse lose telomeric sequences but retain some minor satellite DNA in the pericentromeric area Chromosoma 103 IssueID10 685–692 Occurrence Handle10.1007/s004120050080 Occurrence Handle1:CAS:528:DyaK2MXosFCitbw%3D Occurrence Handle7664615

    Article  CAS  PubMed  Google Scholar 

  • S Garagna N Marziliano M Zuccotti JB Searle E Capanna et al. (2001) ArticleTitlePericentromeric organization at the fusion point of mouse Robertsonian translocation chromosomes Proc Natl Acad Sci USA 98 IssueID1 171–175 Occurrence Handle10.1073/pnas.98.1.171 Occurrence Handle1:CAS:528:DC%2BD3MXkslKqtw%3D%3D Occurrence Handle11136254

    Article  CAS  PubMed  Google Scholar 

  • ND Hastie (1996) Highly repeated DNA families in the genome of Mus musculus MF Lyon S Rastan SDM Brown (Eds) Genetic variants and strains of laboratory mouse, Vol 2 EditionNumber3 Oxford University Press Oxford 1425–1442

    Google Scholar 

  • T Hubbard D Barker E Birney G Cameron Y Chen et al. (2002) ArticleTitleThe Ensembl genome database project Nucleic Acids Res 30 IssueID1 38–41 Occurrence Handle10.1093/nar/30.1.38 Occurrence Handle1:CAS:528:DC%2BD38Xht12ksbY%3D Occurrence Handle11752248

    Article  CAS  PubMed  Google Scholar 

  • WG Hunt RK Selander (1973) ArticleTitleBiochemical genetics of hybridisation in European house mice Heredity 3 11–33

    Google Scholar 

  • M Kapoor R Montes de Oca Luna G Liu G Lozano C Cummings et al. (1998) ArticleTitleThe cenpB gene is not essential in mice Chromosoma 107 IssueID8 570–576 Occurrence Handle10.1007/s004120050343 Occurrence Handle1:CAS:528:DyaK1MXlvVajtw%3D%3D Occurrence Handle9933410

    Article  CAS  PubMed  Google Scholar 

  • D Kipling HE Wilson AR Mitchell BA Taylor HJ Cooke (1994) ArticleTitleMouse centromere mapping using oligonucleotide probes that detect variants of the minor satellite Chromosoma 103 IssueID1 46–55 Occurrence Handle1:CAS:528:DyaK2MXhtlymug%3D%3D Occurrence Handle8013255

    CAS  PubMed  Google Scholar 

  • D Kipling AR Mitchell H Masumoto HE Wilson L Nicol et al. (1995) ArticleTitleCENP-B binds a novel centromeric sequence in the Asian mouse Mus caroli Mol Cell Biol 15 IssueID8 4009–4020 Occurrence Handle1:CAS:528:DyaK2MXntVGisbo%3D Occurrence Handle7623797

    CAS  PubMed  Google Scholar 

  • AM Laurent B Marçais M Muleris G Roizes (1994) ArticleTitleA rapid and simple method to isolate and characterize highly polymorphic markers from the centromeric regions of the human chromosomes Nucleic Acids Res 22 IssueID2 194–199 Occurrence Handle1:CAS:528:DyaK2cXitlOitL8%3D Occurrence Handle8121804

    CAS  PubMed  Google Scholar 

  • AM Laurent J Puechberty C Prades S Gimenez G Roizes (1997) ArticleTitleSite-specific retrotransposition of L1 elements within human alphoid satellite sequences Genomics 46 IssueID1 127–132 Occurrence Handle10.1006/geno.1997.4987 Occurrence Handle1:CAS:528:DyaK2sXnvVCrtb0%3D Occurrence Handle9403067

    Article  CAS  PubMed  Google Scholar 

  • T Lenormand F Fel-Clair K Manolakou P Alibert J Britton–Davidian (1997) ArticleTitleChromosomal transmission bias in laboratory hybrids between wild strains of the two European subspecies of house mice Genetics 147 IssueID3 1279–1287 Occurrence Handle1:STN:280:DyaK1c%2FktlCiug%3D%3D Occurrence Handle9383070

    CAS  PubMed  Google Scholar 

  • HS Malik S Henikoff (2002) ArticleTitleConflict begets complexity: the evolution of centromeres Curr Opin Genet Dev 12 IssueID6 711–718 Occurrence Handle10.1016/S0959-437X(02)00351-9 Occurrence Handle1:CAS:528:DC%2BD38XosFOhs7s%3D Occurrence Handle12433586

    Article  CAS  PubMed  Google Scholar 

  • H Masumoto H Masukata Y Muro N Nozaki T Okazaki (1989) ArticleTitleA human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite J Cell Biol 109 IssueID5 1963–1973 Occurrence Handle10.1083/jcb.109.5.1963 Occurrence Handle1:CAS:528:DyaL1MXmt1Olsr8%3D Occurrence Handle2808515

    Article  CAS  PubMed  Google Scholar 

  • AR Mitchell (1996) ArticleTitleThe mammalian centromere: its molecular architecture Mutat Res 372 IssueID2 153–162 Occurrence Handle1:CAS:528:DyaK28Xnt1Oitb8%3D Occurrence Handle9015134

    CAS  PubMed  Google Scholar 

  • X Montagutelli (1990) ArticleTitleGENE-LINK: a program in PASCAL for backcross genetic analysis J Hered 81 IssueID6 490–491 Occurrence Handle1:STN:280:By6D28ngs1M%3D

    CAS  Google Scholar 

  • Mouse Genome Database (MGD) (1999) Chromosome 11 Committee Reports, Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME. http://www.informatics.jax.org/ccr

  • MW Nachman JB Searle (1995) ArticleTitleWhy is the mouse karyotype so variable? Trends Ecol Evol 10 IssueID10 397–402 Occurrence Handle10.1016/S0169-5347(00)89155-7

    Article  Google Scholar 

  • V Nancé F Vanlerberghe JT Nielsen F Bonhomme J Britton–Davidian (1990) ArticleTitle“Chromosomal introgression in house mice from the hybrid zone between M. m. domesticus and M. m. musculus in Denmark Biol J Linn Soci 41 215–227

    Google Scholar 

  • RB Nicklas (1997) ArticleTitleHow cells get the right chromosomes Science 275 IssueID5300 632–637 Occurrence Handle10.1126/science.275.5300.632 Occurrence Handle1:CAS:528:DyaK2sXptVOlsw%3D%3D Occurrence Handle9005842

    Article  CAS  PubMed  Google Scholar 

  • C Prades AM Laurent J Puechberty Y Yurov G Roizes (1996) ArticleTitleSINE and LINE within human centromeres J Mol Evol 42 IssueID1 37–43 Occurrence Handle10.1007/BF00163209 Occurrence Handle1:CAS:528:DyaK28XntFOmsw%3D%3D Occurrence Handle8576962

    Article  CAS  PubMed  Google Scholar 

  • J Pialek HC Hauffe JB Searle (.) ArticleTitleChromosomal variation in the house mouse: a review Biol J Linn Soc (special volume) . .

    Google Scholar 

  • N Raufaste A Orth K Belkhir D Senet C Smadja et al. (.) ArticleTitleInferences of selection and migration in the Danish house mouse hybrid zone Biol J Linn Soci (special volume) . .

    Google Scholar 

  • CA Redi S Garagna G Della Valle G Bottiroli P Dell’Orto et al. (1990) ArticleTitleDifferences in the organization and chromosomal allocation of satellite DNA between the European long tailed house mice Mus domesticus and Mus musculus Chromosoma 99 IssueID1 11–17 Occurrence Handle1:CAS:528:DyaK3cXlt1yhsr0%3D Occurrence Handle1971208

    CAS  PubMed  Google Scholar 

  • MG Schueler AW Higgins MK Rudd K Gustashaw HF Willard (2001) ArticleTitleGenomic and genetic definition of a functional human centromere Science 294 IssueID5540 109–115 Occurrence Handle10.1126/science.1065042 Occurrence Handle1:CAS:528:DC%2BD3MXnsFyitr4%3D Occurrence Handle11588252

    Article  CAS  PubMed  Google Scholar 

  • P Slijepcevic (1998) ArticleTitleTelomeres and mechanisms of Robertsonian fusion Chromosoma 107 IssueID2 136–140 Occurrence Handle10.1007/s004120050289 Occurrence Handle1:CAS:528:DyaK1cXjtFSkt70%3D Occurrence Handle9601982

    Article  CAS  PubMed  Google Scholar 

  • CE Sunkel PA Coelho (1995) ArticleTitleThe elusive centromere: sequence divergence and functional conservation Curr Opin Genet Dev 5 IssueID6 756–767 Occurrence Handle10.1016/0959-437X(95)80008-S Occurrence Handle1:CAS:528:DyaK2MXhtVSjtLnE Occurrence Handle8745074

    Article  CAS  PubMed  Google Scholar 

  • P Tucker R Sage J Waener A Wilson E Eicher (1992) ArticleTitleAbrupt cline for sex-chromosomes in a hybrid zone between two species of mice Evolution 46 IssueID4 1146–1163

    Google Scholar 

  • F Vanlerberghe P Boursot J Catalan S Gerasimov F Bonhomme et al. (1988) ArticleTitleAnalyse génétique de la zone d’hybridation entre les deux sous-espèces de souris Mus musculus domesticus et Mus musculus musculus en Bulgarie Genome 30 427–437 Occurrence Handle1:STN:280:BiaD3cnitFQ%3D Occurrence Handle3169546

    CAS  PubMed  Google Scholar 

  • BK Vig (1994) ArticleTitleDo specific nucleotide bases constitute the centromere? Mutat Res 309 IssueID1 1–10 Occurrence Handle1:CAS:528:DyaK2cXlsV2rtr4%3D Occurrence Handle7519725

    CAS  PubMed  Google Scholar 

  • CM Wade EJ Kulbokas AW Kirby MC Zody JC Mullikin et al. (2002) ArticleTitleThe mosaic structure of variation in the laboratory mouse genome Nature 420 IssueID6915 574–578 Occurrence Handle10.1038/nature01252 Occurrence Handle1:CAS:528:DC%2BD38Xpt1WhsL4%3D Occurrence Handle12466852

    Article  CAS  PubMed  Google Scholar 

  • BC Williams TD Murphy ML Goldberg GH Karpen (1998) ArticleTitleNeocentromere activity of structurally acentric mini-chromosomes in Drosophila Nat Genet 18 IssueID1 30–37 Occurrence Handle10.1038/ng0198-30 Occurrence Handle1:CAS:528:DyaK1cXivFemtA%3D%3D Occurrence Handle9425896

    Article  CAS  PubMed  Google Scholar 

  • J Zima VA Gaichenko M Macholan SI Radjabli OV Sablina (1990) ArticleTitleAre Robertsonian variations a frequent phenomenon in mouse populations in Eurasia? Biol J Linn Soc 41 229–233

    Google Scholar 

Download references

Acknowledgments

The authors wish to thank Dr. Guila Ganem for assistance during field collection and for providing some of the samples used in this study, Dr. Janice Britton–Davidian for helpful discussion and comments about this work, and two anonymous referees for their constructive comments and corrections on the final manuscript.

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  1. Isabelle Lanneluc Erick Desmarais

    Present address: Laboratoire de Biotechnologies et de Chimie Bio-organique, Université de La Rochelle, Av M. Crépeau, La Rochelle Cedex 01, 17042, France

Authors and Affiliations

  1. Laboratoire Génome Populations Interactions Adaptation (UMR 5171 CNRS-UM2-IFREMER), Université de Montpellier II C.C. 63, Place E. Bataillon, Montpellier Cedex 5, 34095, France

    Isabelle Lanneluc Erick Desmarais, Pierre Boursot, Barbara Dod & François Bonhomme

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  1. Isabelle Lanneluc Erick Desmarais
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Two first authors contributed equally to this work.

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Desmarais, I.E., Boursot, P., Dod, B. et al. Characterization of a centromeric marker on mouse Chromosome 11 and its introgression in a domesticus/musculus hybrid zone. Mamm Genome 15, 924–934 (2004). https://doi.org/10.1007/s00335-004-2397-x

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  • DOI: https://doi.org/10.1007/s00335-004-2397-x

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