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Characterization of a centromeric marker on mouse Chromosome 11 and its introgression in a domesticus/musculus hybrid zone

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Abstract

It has been proposed that the distribution of Robertsonian chromosome fusions and the Chromosome 11 Nucleolar Organizer Region (NOR) in the Danish hybrid zone between M. m. musculus and M. m. domesticus stems from centromeric incompatibilities between the two subspecies. To test this hypothesis, we identified and characterized a diagnostic subspecific marker closely linked to the centromere on mouse Chromosome 11. Using an allele-specific PCR assay, we investigated the introgression pattern of this centromere in a large sample of mice from a North–South transect of the hybrid zone in Jutland. Domesticus alleles were found to introgress far away from the center of the zone on the musculus side. These results suggest there is no incompatibility between the domesticus centromere of Chromosome 11 in the musculus genomic background.

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Acknowledgments

The authors wish to thank Dr. Guila Ganem for assistance during field collection and for providing some of the samples used in this study, Dr. Janice Britton–Davidian for helpful discussion and comments about this work, and two anonymous referees for their constructive comments and corrections on the final manuscript.

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  1. Isabelle Lanneluc Erick Desmarais

    Present address: Laboratoire de Biotechnologies et de Chimie Bio-organique, Université de La Rochelle, Av M. Crépeau, La Rochelle Cedex 01, 17042, France

Authors and Affiliations

  1. Laboratoire Génome Populations Interactions Adaptation (UMR 5171 CNRS-UM2-IFREMER), Université de Montpellier II C.C. 63, Place E. Bataillon, Montpellier Cedex 5, 34095, France

    Isabelle Lanneluc Erick Desmarais, Pierre Boursot, Barbara Dod & François Bonhomme

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  1. Isabelle Lanneluc Erick Desmarais
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  2. Pierre Boursot
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Two first authors contributed equally to this work.

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Desmarais, I.E., Boursot, P., Dod, B. et al. Characterization of a centromeric marker on mouse Chromosome 11 and its introgression in a domesticus/musculus hybrid zone. Mamm Genome 15, 924–934 (2004). https://doi.org/10.1007/s00335-004-2397-x

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  • DOI: https://doi.org/10.1007/s00335-004-2397-x

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