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Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6

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Abstract

Iddm4 is one of several susceptibility genes that have been identified in the BB rat model of type 1 diabetes. The BB rat allele of this gene confers dominant predisposition to diabetes induction by immune perturbation in both the diabetes-prone and the diabetes-resistant substrains, whereas the Wistar Furth (WF) allele confers resistance. We have positioned the gene in a 2.8-cM region on rat Chromosome (Chr) 4, proximal to Lyp/Ian4l1. We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs. We present a comparative map of the rat Iddm4 region in rat, human, and mouse, assigning the gene to a 6.3-Mb segment between PTN and ZYX at 7q32 in the human genome, and to a 5.7-Mb segment between Ptn and Zyx in the mouse genome.

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Notes

  1. Also referred to as Iddm1 or Iddm2 depending on authors. According to a revision made by the Rat Genome and Nomenclature Committee, it should be referred to as Iddm2, while Iddm1 should refer to the MHC-related susceptibility locus vis-à-vis IDDM1 in human and Iddm1 in mouse.

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Acknowledgements

This work was supported by Research Grant 1-2002-458 from the Juvenile Diabetes Foundation International. The Hagedorn Research Institute is an independent basic research component of Novo Nordisk a/s. This work was also supported in part by grants DK49106 (D.L. Greiner, J.P. Mordes, E.P. Blankenhorn), DK 36024 (D.L. Greiner), DK25306 (J.P. Mordes), and Center Grant DK32520 from the National Institutes of Health. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. We thank Sanne Rasmussen and Michael Bates for technical assistance.

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Authors and Affiliations

  1. Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark

    Lars Hornum & Helle Markholst

  2. Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA

    Cheryl DeScipio, Scott A. Troutman, Stephen Novak & Elizabeth P. Blankenhorn

  3. Diabetes Division, University of Massachusetts Medical School, 373 Plantation Street, #218, Worcester, Massachusetts, USA

    Jean Leif, Dale Greiner & John P. Mordes

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  1. Lars Hornum
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  2. Cheryl DeScipio
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  3. Helle Markholst
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  4. Scott A. Troutman
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  5. Stephen Novak
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  6. Jean Leif
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  7. Dale Greiner
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  8. John P. Mordes
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  9. Elizabeth P. Blankenhorn
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Correspondence to Helle Markholst.

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Hornum, L., DeScipio, C., Markholst, H. et al. Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6 . Mamm Genome 15, 53–61 (2004). https://doi.org/10.1007/s00335-003-3023-z

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  • DOI: https://doi.org/10.1007/s00335-003-3023-z

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