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An autoimmune diabetes locus (Idd21) on mouse Chromosome 18

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Abstract

Twenty-four named Idd loci that contribute to the development of autoimmune diabetes in the nonobese diabetic (NOD) mouse have been mapped by linkage and congenic analysis. Previously, meta-analysis of genome-wide linkage scans supported the existence of a locus for susceptibility to autoimmune phenotypes on rodent Chromosome (Chr) 18, in a position orthologous to the human type 1 diabetes susceptibility locus IDDM6 (human Chr 18q12-q23). However, an autoimmune diabetes susceptibility locus has not previously been reported on mouse Chr 18. In this study, we demonstrate linkage of the majority of mouse Chr 18 to diabetes in a (ABH × NOD)F1 × NOD backcross. Congenic analysis, introgressing at least 92% of Biozzi ABH Chr 18 onto the NOD background, confirmed the presence of a diabetes locus. The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21.

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Acknowledgements

The authors thank the New Zealand Health Research Council, the New Zealand Lottery Grants Board, and the University of Otago for financial support. Staff at the Department for Laboratory and Animal Science, University of Otago, are thanked for expert technical assistance.

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Authors and Affiliations

  1. Department of Biochemistry, University of Otago, Dunedin, New Zealand

    Richard J. Hall, Jade E. Hollis-Moffatt, Marilyn E. Merriman, Rachel A. Green & Tony R. Merriman

  2. Department of Neuroinflammation, Institute of Neurology, University College London, London, UK

    David Baker

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  1. Richard J. Hall
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  2. Jade E. Hollis-Moffatt
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  3. Marilyn E. Merriman
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  4. Rachel A. Green
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  5. David Baker
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  6. Tony R. Merriman
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Correspondence to Tony R. Merriman.

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Hall, R.J., Hollis-Moffatt, J.E., Merriman, M.E. et al. An autoimmune diabetes locus (Idd21) on mouse Chromosome 18 . Mamm Genome 14, 335–339 (2003). https://doi.org/10.1007/s00335-002-3064-8

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  • DOI: https://doi.org/10.1007/s00335-002-3064-8

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