Skip to main content
Log in

Stripping away the mysteries of the brain’s insulation: might T1-FFLAIR improve our understanding of prenatal myelination?

  • Commentary
  • Published:
European Radiology Aims and scope Submit manuscript

The Original Article was published on 29 November 2023

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Griffiths PD, Bradburn M, Campbell MJ et al (2017) Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: analysis of the MERIDIAN cohort. Clin Radiol. https://doi.org/10.1016/j.crad.2017.01.009

    Article  PubMed  Google Scholar 

  2. Rajagopalan V, Deoni S, Panigrahy A, Thomason ME (2021) Is fetal MRI ready for neuroimaging prime time? An examination of progress and remaining areas for development. Dev Cogn Neurosci. https://doi.org/10.1016/j.dcn.2021.100999

    Article  PubMed  PubMed Central  Google Scholar 

  3. Williamson JM, Lyons DA (2018) Myelin dynamics throughout life: an ever-changing landscape? Front Cell Neurosci. https://doi.org/10.3389/fncel.2018.00424

    Article  PubMed  PubMed Central  Google Scholar 

  4. Moltoni G, Talenti G, Righini A (2021) Brain fetal neuroradiology: a beginner’s guide. Transl Pediatr. https://doi.org/10.21037/tp-20-293

    Article  PubMed  PubMed Central  Google Scholar 

  5. Duncan ID, Radcliff AB (2016) Inherited and acquired disorders of myelin: the underlying myelin pathology. Exp Neurol. https://doi.org/10.1016/j.expneurol.2016.04.002

    Article  PubMed  PubMed Central  Google Scholar 

  6. Jakovcevski I, Filipovic R, Mo Z et al (2009) Oligodendrocyte development and the onset of myelination in the human fetal brain. Front Neuroanat. https://doi.org/10.3389/neuro.05.005.2009

    Article  PubMed  PubMed Central  Google Scholar 

  7. Darbinian N, Selzer ME (2022) Oligodendrocyte pathology in fetal alcohol spectrum disorders. Neural Regen Res. https://doi.org/10.4103/1673-5374.314294

    Article  PubMed  Google Scholar 

  8. Georgieff MK (2020) Iron deficiency in pregnancy. Am J Obstet Gynecol. https://doi.org/10.1016/j.ajog.2020.03.006

    Article  PubMed  PubMed Central  Google Scholar 

  9. Garel C, Chantrel E, Elmaleh M et al (2003) Fetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination. Childs Nerv Syst. https://doi.org/10.1007/s00381-003-0767-4

    Article  PubMed  Google Scholar 

  10. Rueda-Lopes FC, Hygino da Cruz LC, Doring TM, Gasparetto EL (2014) Diffusion-weighted imaging and demyelinating diseases: new aspects of an old advanced sequence. AJR Am J Roentgenol. https://doi.org/10.2214/AJR.13.11400

    Article  PubMed  Google Scholar 

  11. Milos R-I, Schmidbauer V, Watzenboeck ML et al (2023) T1-weighted fast fluid-attenuated inversion-recovery sequence (T1-FFLAIR) enables the visualization and quantification of fetal brain myelination in utero. Eur Radiol. https://doi.org/10.1007/s00330-023-10401-z

    Article  PubMed  Google Scholar 

  12. Vranic JE, Cross NM, Wang Y et al (2019) Compressed sensing-sensitivity encoding (CS-SENSE) accelerated brain imaging: reduced scan time without reduced image quality. AJNR Am J Neuroradiol. https://doi.org/10.3174/ajnr.A5905

    Article  PubMed  PubMed Central  Google Scholar 

  13. Yarnykh VL, Prihod’ko IY, Savelov AA, Korostyshevskaya AM (2018) Quantitative assessment of normal fetal brain myelination using fast macromolecular proton fraction mapping. AJNR Am J Neuroradiol. https://doi.org/10.3174/ajnr.A5668

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

The author states that this work has not received any funding. This work was supported by the NIH (Human Placenta Project—grant 1U01HD087202-01), Wellcome Trust Sir Henry Wellcome Fellowship (201374/Z/16/Z and /B), UKRI FLF (MR/T018119/1), DFG Heisenberg funding [502024488], EPSRC (EP/V034537/1), the NIHR Clinical Research Facility (CRF) at Guy’s and St Thomas’ and by core funding from the Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z] and by the National Institute for Health Research (NIHR) Clinical Research Facility based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS or the NIHR or the Department of Health and Social Care.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kelly Payette.

Ethics declarations

Guarantor

The scientific guarantor of this publication is Kelly Payette.

Conflict of interest

The author of this manuscript declares no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was not required.

Ethical approval

Institutional Review Board approval was not required.

Study subjects or cohorts overlap

Not applicable

Methodology

• commentary

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This comment refers to the article available at https://doi.org/10.1007/s00330-023-10401-z.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Payette, K. Stripping away the mysteries of the brain’s insulation: might T1-FFLAIR improve our understanding of prenatal myelination?. Eur Radiol (2023). https://doi.org/10.1007/s00330-023-10450-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00330-023-10450-4

Navigation