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Comparison of MRI response evaluation methods in rectal cancer: a multicentre and multireader validation study

  • Gastrointestinal
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Abstract

Objectives

To compare four previously published methods for rectal tumor response evaluation after chemoradiotherapy on MRI.

Methods

Twenty-two radiologists (5 rectal MRI experts, 17 general/abdominal radiologists) retrospectively reviewed the post-chemoradiotherapy MRIs of 90 patients, scanned at 10 centers (with non-standardized protocols). They applied four response methods; two based on T2W-MRI only (MRI tumor regression grade (mrTRG); split-scar sign), and two based on T2W-MRI+DWI (modified-mrTRG; DWI-patterns). Image quality was graded using a 0–6-point score (including slice thickness and in-plane resolution; sequence angulation; DWI b-values, signal-to-noise, and artefacts); scores < 4 were classified below average. Mixed model linear regression was used to calculate average sensitivity/specificity/accuracy to predict a complete response (versus residual tumor) and assess the impact of reader experience and image quality. Group interobserver agreement (IOA) was calculated using Krippendorff’s alpha. Readers were asked to indicate their preferred scoring method(s).

Results

Average sensitivity/specificity/accuracy was 57%/64%/62% (mrTRG), 36%/79%/66% (split-scar), 40%/79%/67% (modified-mrTRG), and 37%/82%/68% (DWI-patterns); mrTRG showed higher sensitivity but lower specificity and accuracy (p < 0.001) compared to the other methods. IOA was lower for the split scar method (0.18 vs. 0.39–0.43). Higher reader experience had a significant positive effect on diagnostic performance and IOA (except for the split scar sign); below-average imaging quality had a significant negative effect on diagnostic performance. DWI pattern was selected as the preferred method by 73% of readers.

Conclusions

Methods incorporating DWI showed the most favorable results when combining diagnostic performance, IOA, and reader preference. Reader experience and image quality clearly impacted diagnostic performance emphasizing the need for state-of-the-art imaging and dedicated radiologist training.

Key Points

In a multireader study comparing 4 MRI methods for rectal tumor response evaluation, those incorporating DWI showed the best results when combining diagnostic performance, IOA, and reader preference.

The most preferred method (by 73% of readers) was the “DWI patterns” approach with an accuracy of 68%, high specificity of 82%, and group IOA of 0.43.

• Reader experience level and MRI quality had an evident effect on diagnostic performance and IOA.

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Abbreviations

CRT:

Chemoradiotherapy

DWI:

DIFFUSION-weighted imaging

IOA:

Interobserver agreement

mrTRG:

MRI tumor regression grade

NPV:

Negative predictive value

PPV:

Positive predictive value

W&W:

Watch & Wait

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Acknowledgments

Other authors in the study group:

Frans C. H. Bakers1; Perla Barros2; Ferdinand Bauer3; Shira H. de Bie4; Stuart Ballantyne5; Joanna Brayner Dutra6,7; Laura Buskov8; Nino Bogveradze9,10,11; Gerlof P. T. Bosma12; Vincent C. Cappendijk13; Francesca Castagnoli14; Sotiriadis Charalampos15; Andrea Delli Pizzi26; Michael Digby17; Remy W. F. Geenen18; Joost J. M. van Griethuysen9,19; Julie Lafrance20; Vandana Mahajan21; Sonaz Malekzadeh22; Peter A. Neijenhuis23; Gerald M. Peterson24; Indra Pieters25; Niels W. Schurink9,10; Ruth Smit26; Cornelis J. Veeken27; Roy F. A. Vliegen28; Andrew Wray29; Abdel-Rauf Zeina30

1Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands

2Department of Radiology, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile

3.Radiologie Zentrum, Kaufbeuren , Germany

4Department of Radiology, Deventer Ziekenhuis, The Netherlands

5Department of Radiology, Queen Elizabeth University Hospital, Glasgow, United Kingdom

6Department of Radiology, Real Hospital Portugues (RHP), Pernambuco, Brazil

7Department of Radiology, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.

8.Department of Radiology, Bispebjerg Hospital, Copenhagen, Denmark

9Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

10GROW School for Oncology & Developmental Biology, University of Maastricht, Maastricht, The Netherlands

11Department of Radiology, American Hospital Tbilisi, Tbilisi, Georgia

12Department of Radiologie Elisabeth Tweesteden Hospital, Tilburg, The Netherlands

13Department of Radiology, Jeroen Bosch Hospital, ‘s Hertogenbosch, The Netherlands

14Department of Radiology, University of Brescia, Brescia, Italy

15Department of Radiology, Hôpital Riviera Chablais, Rennaz, Switzerland

16Department of Innovative Technologies in Medicine & Dentistry, Gabriele d’Annunzio University of Chieti, Chieti, Italy

17Department of Radiology, Glasgow Royal Infirmary, Glasgow, United Kingdom.

18Department of Radiology, Northwest Clinics, Alkmaar, The Netherlands

19Department of Radiology, Gelre Hospital, Apeldoorn, The Netherlands

20Department of Radiology, Maisonneuve-Rosemont Hospital, Montreal, Canada

21Department of Radiology, Apollo Cancer Hospital, Chennai, India

22Department of Radiology, Sion Hospital, Sion, Switzerland

23Department of Surgery, Alrijne Hospital, Leiderdorp, The Netherlands

24Department of Radiology, Spaarne Gasthuis, Haarlem, The Netherlands

25Department of Radiology, Telemedicine Clinic, United Kingdom

26Department of Radiology, Amsterdams UMC, Amsterdam, The Netherlands

27Department of Radiology, IJsselland Hospital, Capelle aan den IJssel, The Netherlands

28Department of Radiology, Zuyderland Medical Center, Heerlen, The Netherlands

29Department of Radiology, Ulster Hospital, Belfast, United Kingdom

30.Department of Radiology, Hillel Yaffe Medical Center, Hadera, Israel

Funding

The authors state that this work has not received any funding.

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Correspondence to Doenja M. J. Lambregts.

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Guarantor

The scientific guarantor of this publication is Dr Doenja MJ Lambregts.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors, Mr Renaud Tissier, has significant statistical expertise.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Institutional Review Board approval was obtained.

Study subjects or cohorts overlap

Some study subjects included in the current cohort have been previously reported on the following:

n = 90 in a study focused on retrospectively evaluating staging trends in the Netherlands following guidelines updates (Bogveradze et al Abdom Radiol (New York). 2022;47(1):38-47).

n = 11 in a study focused on common interpretation pitfalls in rectal DWI and their use for teaching (Lambregts et al Eur Radiol 2017; 27, 4445–4454)

n = 80 in a technical study focused on assessing the reproducibility of quantitative imaging features in multicentre study cohorts (Schurink et al Eur Radiol. 2022;32(3):1506-1516).

n = 6 in a study focused on assessing the sigmoid take-off as a landmark to distinguish rectal from sigmoid tumors on MRI (Bogveradze et al Eur J Surg Oncol 2022;48:237-244)

n = 16 in a single-center pilot study investigating the DWI pattern method (Lambregts et al Dis Colon Rectum 2018;61(3):328-337).

Methodology

• retrospective

• observational

• multicentre study

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El Khababi, N., Beets-Tan, R.G.H., Tissier, R. et al. Comparison of MRI response evaluation methods in rectal cancer: a multicentre and multireader validation study. Eur Radiol 33, 4367–4377 (2023). https://doi.org/10.1007/s00330-022-09342-w

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