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The influence of cardiac motion on radiomics features: radiomics features of non-enhanced CMR cine images greatly vary through the cardiac cycle

European Radiology volume 31, pages 2706–2715 (2021)Cite this article

Abstract

Objectives

The cardiac cycle might impair the reproducibility of radiomics features of cardiac magnetic resonance (CMR) cine images, yet this issue has not been addressed in the previous research. We aim to evaluate whether radiomics features of CMR cine images vary during the cardiac cycle and investigate the reproducibility of radiomics features of CMR cine images.

Methods

This retrospective study enrolled 59 healthy adults who underwent CMR examination. Two observers segmented the myocardium on a 4D stack of three consecutive mid-ventricular short-axis cine images covering the cardiac cycle. A total of 352 radiomics features were extracted. The coefficient of variation and intraclass correlation coefficient were used to assess the feature variability through the cycle and inter-observer reproducibility, respectively.

Results

Approximately 55% of radiomics features showed large variability through the cardiac cycle. The original features showed more variability than the Laplacian of Gaussian-filtered features (73.8% vs. 48%). The features of 4D stack cine images had a higher proportion of reproducible features (92.0%, 87.7%, and 76.1%) compared with the end-diastolic (77.8%, 62.2%, and 41.7%) and the end-systolic images (81.5%, 74.1%, and 58.8%) for intraclass correlation cut-off values of 30.80, > 0.85, and > 0.90, respectively.

Conclusions

Radiomics features of CMR cine images greatly vary during the cardiac cycle. The radiomics features of 4D stack of cine images are more robust compared with end-diastolic and end-systolic cine images in terms of reproducibility. The impact of the cardiac cycle on the reproducibility of the features should be considered when employing CMR cine images radiomics.

Key Points

• There is limited evidence on the impact of cardiac motion on radiomics features of CMR cine images and the reproducibility of the radiomics features of CMR cine images.

• Radiomics features of non-enhanced CMR cine images greatly vary during the cardiac cycle, and the number of “reproducible” features shows significant variations according to the cardiac phases.

• The impact of cardiac cycle on the reproducibility of the radiomics features should be considered when employing CMR cine images radiomics.

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Fig. 1
Fig. 2

Abbreviations

CMR:

Cardiac magnetic resonance

COV:

Coefficient of variation

DSC:

Dice similarity coefficient

GLCM:

Gray level co-occurrence matrix

GLDM:

Gray level dependence matrix

GLSZM:

Gray level size zone matrix

GRLM:

Gray level run length matrix

ICC:

Intraclass correlation coefficient

IQR:

Interquartile range

LoG:

Laplacian of Gaussian

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Funding

The authors state that this work has not received any funding.

Author information

Affiliations

  1. Department of Radiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey

    Deniz Alis & Ercan Karaarslan

  2. Department of Software Engineering and Applied Sciences, Bahcesehir University, Istanbul, Turkey

    Mert Yergin

  3. Department of Radiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Halkali, Istanbul, Turkey

    Ozan Asmakutlu & Cagdas Topel

Authors
  1. Deniz Alis
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  2. Mert Yergin
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  3. Ozan Asmakutlu
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  4. Cagdas Topel
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  5. Ercan Karaarslan
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Corresponding author

Correspondence to Deniz Alis.

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Guarantor

The scientific guarantor of this publication is Deniz Alis.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

Two authors (D.A. and M.Y.) have significant statistical expertise.

Informed consent

Written informed consent was waived by the Institutional Review Board. Approval from the institutional animal care committee was not required.

Ethical approval

Institutional Review Board approval was obtained from Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital ethics committee.

Methodology

• retrospective

• cross-sectional study/experimental

• performed at one institution

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Alis, D., Yergin, M., Asmakutlu, O. et al. The influence of cardiac motion on radiomics features: radiomics features of non-enhanced CMR cine images greatly vary through the cardiac cycle. Eur Radiol 31, 2706–2715 (2021). https://doi.org/10.1007/s00330-020-07370-y

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  • DOI: https://doi.org/10.1007/s00330-020-07370-y

Keywords

  • Artificial ıntelligence
  • Cine MRI
  • Radiomics
  • Reproducibility of results
  • Observer variation