Skip to main content

Table 1 Demographics and clinical characteristics

From: Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders

  HC NMOSD-NON NMOSD-ON p
Number 37 14 25
Age, years (mean, SD) 47.8 (12.6) 53.8 (12.5) 48.09 (14.9) 0.33
Sex (F/M) (% female) 30/7 (81%) 14/0 (100%) 21/4 (84%) 0.22
Disease duration, years (median, range) 7.1 (3–34.1)  
Number of ON (median, range) 2 (1–12)
Time since first ON, years (median, range) 6.9 (3.4–32.2)
Time since last ON, years (median, range) 4.9 (0.5–13.2)
ON involvement, bilateral/unilateral 11/14
(8 right/6 left)
Optic nerve diameter, mm (mean, SD) 8.37 (0.50) 8.13 (0.90) 7.06 (1.23) < 0.001
pRNFL, μm (mean, SD) 91.99 (15.10) 97.96 (10.13) 67.57 (17.92) < 0.001
GCIPL mm3 (mean, SD) 1.83 (0.28) 1.88 (0.14) 1.49 (0.25) < 0.001
Visual acuity, logMAR (mean, SD) − 0.01 (0.21) −0.15 (0.21) 0.30 (0.63) 0.04
Visual Functional System Score (median, range) 0 (0–2) 1 (0–6) < 0.001
EDSS (median, range) 3 (1–7) 4 (0–6.5) 0.71
  1. p values are groupwise comparisons. HC = healthy controls; NMOSD-ON = neuromyelitis optica patients with history of optic neuritis; NMOSD-NON = neuromyelitis optica patients without history of optic neuritis; ON = optic neuritis; pRNFL = peripapillary retinal nerve fiber layer; GCIPL = combined ganglion cell-inner plexiform layer; logMAR = logarithm of the minimum angle of resolution; EDSS = Expanded Disability Status Scale