The clinical utility of electronically derived ASPECTS (e-ASPECTS) to quantify signs of acute ischemic infarction could be demonstrated in multiple studies. Here, we aim to clinically validate the impact of CT slice thickness (ST) on the performance of e-ASPECTS software.
A consecutive series of n = 258 patients (06/2016 and 01/2019) with middle cerebral artery occlusion and subsequent treatment with mechanical thrombectomy was analyzed. The e-ASPECTS score and acute infarct volumes were calculated from baseline non-contrast CT with a software using 1-mm slice thickness (ST) (defined as ground truth) and axial reconstructions with 2–10-mm ST and correlated with baseline stroke severity (NIHSS) as well as clinical outcome (mRS) using logistic regressions.
In comparison with the ground truth, significant differences were seen in e-ASPECTS scores with ST > 6 mm (p ≤ 0.031) and infarct volumes with ST > 4 mm (p ≤ 0.001). There was a significant correlation of lower e-ASPECTS and higher acute infarct volumes with increasing baseline NIHSS values for all ST (p ≤ 0.001, respectively), with values derived from 1 mm yielding the highest correlation for both parameters (rho, − 0.38 and 0.31, respectively). Similarly, lower e-ASPECTS and higher acute infarct volumes from all ST were significantly associated with poor outcome after 90 days (p ≤ 0.05, respectively) with values derived from 1-mm ST yielding the highest effects for both parameters (OR, 0.69 [95% CI 0.50–0.88] and 1.27 [95% CI 1.10–1.50], respectively).
The e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.
• Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.
• Thin slices (= 1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation with baseline stroke severity and independent effects on clinical outcome after 90 days.
• Automatically calculated acute infarct volumes possess clinical utility beyond ASPECTS and should be considered in future studies.
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Acute ischemic stroke
Alberta Stroke Program Early CT Score
Electronically derived Alberta Stroke Program Early CT Scores
Modified Rankin scale
Modified thrombolysis in cerebral infarction
Non-contrast-enhanced computerized tomography
National Institutes of Health Stroke Scale
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Dr. Kickingereder, MBA, was supported by the Else Kröner-Fresenius Foundation (Else Kröner Memorial Scholarship).
The scientific guarantors of this publication are Dr. Philipp Kickingereder, MBA and Dr. Ulf Neuberger.
Conflict of interest
Dr. Nagel received grants, personal fees, and other from Brainomix; personal fees and other from Bayer, personal fees and other from Bohringer Ingelheim; personal fees and other from Medtronic; and personal fees from Pfizer outside of submitted work. Dr. Pfaff has received payment for lectures from the University of Hamburg-Eppendorf and Asklepios Arzteakademie; travel and meeting expenses from Stryker and MicroVention Deutschland. Dr. Bendszus has received grants and personal fees from Novartis, Guerbet, and Codman; personal fees from Vascular Dynamics, Roche, Teva, Springer, and Bayer Vital; grants from Siemens and Hopp Foundation. DFG. Dr. Mohlenbruch has received personal fees from Codman, MicroVention, Phenox, and Stryker. Dr. Herweh received personal fees form Brainomix.
The other authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
One of the authors has significant statistical expertise.
Written informed consent was waived by the Institutional Review Board.
Institutional Review Board approval was obtained at the local ethics committee of the medical faculty of the University of Heidelberg.
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Neuberger, U., Nagel, S., Pfaff, J. et al. Impact of slice thickness on clinical utility of automated Alberta Stroke Program Early Computed Tomography Scores. Eur Radiol 30, 3137–3145 (2020). https://doi.org/10.1007/s00330-019-06616-8
- Brain ischemia
- Image interpretation, computer-assisted
- Tomography, X-ray computed