Abstract
Objectives
The purpose of this study was to investigate which feature of the breast-specific gamma imaging (BSGI) uptake in women who were recently diagnosed with breast cancer was associated with malignancy.
Methods
Data on 231 newly diagnosed breast cancer patients who underwent preoperative BSGI were retrospectively reviewed. Feature analysis was done by classifying BSGI uptake into mass, non-mass, or focus/foci. Descriptors for mass, non-mass, or focus/foci were shape, distribution, number, and intensity. BSGI features of known malignancies and lesions that were additionally found by BSGI were correlated with mammographic breast density, histology, hormonal status, and clinical follow-up data obtained over at least 2 years.
Results
Among 372 breast lesions from 231 patients, 241 malignancies had been pathologically confirmed prior to BSGI and 131 additional lesions were found on BSGI. Irregular shape was more predictive of malignancy than oval shape (p=0.004) in mass uptake. Linear/ductal distribution was more predictive of malignancy than focal, regional, and segmental distribution (p<0.05) in non-mass uptake. Mammographic breast density was not associated with BSGI features. The lesion to normal ratio (LNR) was higher in the postmenopausal patients than that in the premenopausal patients (p=0.003).
Conclusions
The feature analysis of radiotracer uptake in BSGI is useful in predicting whether breast lesions are malignant or benign.
Key Points
• The feature analysis of BSGI uptake is useful in predicting malignancy.
• Irregular shape was predictive of malignancy in mass uptake.
• Linear/ductal distribution was predictive of malignancy in non-mass uptake.
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Abbreviations
- BI-RADS:
-
Breast imaging reporting and data system
- BSGI:
-
Breast-specific gamma imaging
- CC:
-
Craniocaudal
- DCIS:
-
Ductal carcinoma in situ
- IDC:
-
Invasive ductal carcinoma
- LNR:
-
Lesion to normal ratio
- MBI:
-
Molecular breast imaging
- MLO:
-
Mediolateral oblique
- PET:
-
Positron emission tomography
- ROC:
-
Receiver operating characteristics
- ROI:
-
Region of interest
- Tc-99m:
-
MIBI Tc-99m sestamibi
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Funding
This study was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2015M3C7A1064832).
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The scientific guarantor of this publication is Jin Kyoung Oh.
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The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
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No complex statistical methods were necessary for this paper.
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Written informed consent was waived by the Institutional Review Board.
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Institutional Review Board approval was obtained.
Methodology
• retrospective
• observational
• performed at one institution
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Choi, E.K., Im, J.J., Park, C.S. et al. Usefulness of feature analysis of breast-specific gamma imaging for predicting malignancy. Eur Radiol 28, 5195–5202 (2018). https://doi.org/10.1007/s00330-018-5563-3
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DOI: https://doi.org/10.1007/s00330-018-5563-3