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European Radiology

, Volume 28, Issue 12, pp 5160–5170 | Cite as

Left ventricular myocardial deformation in Takotsubo syndrome: a cardiovascular magnetic resonance myocardial feature tracking study

  • Thomas Stiermaier
  • Torben Lange
  • Amedeo Chiribiri
  • Christian Möller
  • Tobias Graf
  • Christina Villnow
  • Uwe Raaz
  • Adriana Villa
  • Johannes T. Kowallick
  • Joachim Lotz
  • Gerd Hasenfuß
  • Holger Thiele
  • Andreas Schuster
  • Ingo EitelEmail author
Cardiac

Abstract

Objectives

This study assessed the applicability and prognostic value of cardiovascular magnetic resonance (CMR) left ventricular deformation analysis in Takotsubo syndrome (TTS).

Methods

CMR-feature tracking was performed blinded in a core laboratory to determine circumferential (CS), radial (RS) and longitudinal strain (LS) in 141 TTS patients participating in this cohort study. A subgroup of consecutive TTS patients (n = 20) was compared with age- and sex-matched controls with anterior ST-segment elevation myocardial infarction (STEMI) and non-STEMI as well as healthy subjects.

Results

Median global CS, RS and LS were -19%, 19% and -12%, respectively. Apical ballooning was associated with significantly lower global CS (p < 0.01) and LS (p < 0.01) compared with midventricular and basal ballooning. Global RS was lowest in patients with basal ballooning (p < 0.01). Segmental analysis resulted in a reliable discrimination of different ballooning patterns using CS and LS. Strain values were significantly lower in TTS compared with non-STEMI patients and healthy subjects, whereas STEMI patients showed similar values. While global CS and RS were not associated with long-term mortality, global LS (cutoff -14.75%) was identified as a potential parameter for long-term risk stratification (mortality rate 17.9% versus 2.5%; p = 0.02).

Conclusions

The transient contraction abnormalities in TTS can be quantitatively assessed with CMR-feature tracking. GLS is a potential determinant of outcome in TTS, which, however, requires further validation.

Key Points

Cardiovascular magnetic resonance myocardial feature tracking enables accurate assessment of regional and global left ventricular dysfunction in Takotsubo syndrome (TTS).

Global strain in TTS is similar to patients with anterior STEMI and lower compared with non-STEMI and healthy subjects.

Global longitudinal strain is a potential tool for risk prediction in TTS patients.

Keywords

Takotsubo cardiomyopathy Ventricular function, left Magnetic resonance imaging Strain Prognosis 

Abbreviations

CMR

Cardiovascular magnetic resonance

CMR-FT

Cardiovascular magnetic resonance myocardial feature tracking

CS

Circumferential strain

GCS

Global circumferential strain

GLS

Global longitudinal strain

GRS

Global radial strain

IQR

Interquartile range

LS

Longitudinal strain

LV

Left ventricular

NSTEMI

Non-ST-segment elevation myocardial infarction

RS

Radial strain

SSFP

Steady state-free precession

STEMI

ST-segment elevation myocardial infarction

TTP

Time to peak

TTE

Transthoracic echocardiography

TTS

Takotsubo syndrome

Notes

Acknowledgments

The authors are grateful for the financial support provided by the German Center for Cardiovascular Research (DZHK).

Funding

This study has received funding by the German Center for Cardiovascular Research (DZHK).

Compliance with ethical standards

Guarantor

The scientific guarantors of this publication are Ingo Eitel and Andreas Schuster.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• Retrospective analysis of prospectively collected data

• Observational diagnostic and prognostic study

• Multicenter study

Supplementary material

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ESM 1 (DOCX 71 kb)
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ESM 2

(TIF 65 kb) (PNG 1.14 mb)

330_2018_5475_MOESM2_ESM.tif (66 kb)
High resolution (TIF 65 kb)

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  • Thomas Stiermaier
    • 1
  • Torben Lange
    • 2
  • Amedeo Chiribiri
    • 3
  • Christian Möller
    • 1
  • Tobias Graf
    • 1
  • Christina Villnow
    • 1
  • Uwe Raaz
    • 2
  • Adriana Villa
    • 3
  • Johannes T. Kowallick
    • 4
  • Joachim Lotz
    • 4
  • Gerd Hasenfuß
    • 2
  • Holger Thiele
    • 5
  • Andreas Schuster
    • 2
    • 6
  • Ingo Eitel
    • 1
    Email author
  1. 1.Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine), University Heart Center Lübeck and German Center for Cardiovascular Research (DZHK)LübeckGermany
  2. 2.Department of Cardiology and Pneumology, University Medical Center Göttingen, Georg-AugustUniversity German Center for Cardiovascular Research (DZHK)GöttingenGermany
  3. 3.Division of Imaging Sciences and Biomedical EngineeringKing’s College LondonLondonUK
  4. 4.Institute for Diagnostic and Interventional Radiology, University Medical Center Göttingen, Georg-August University and German Center for Cardiovascular Research (DZHK)GöttingenGermany
  5. 5.Department of Internal Medicine/CardiologyHeart Center Leipzig – University HospitalLeipzigGermany
  6. 6.The Kolling Institute, Northern Clinical School, Royal North Shore Hospital, Department of CardiologyUniversity of SydneySydneyAustralia

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