Prognostic importance of peritoneal lesion-to-primary tumour standardized uptake value ratio in advanced serous epithelial ovarian cancer
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Using preoperative PET/CT, we evaluated the prognostic value of preoperative [18F]FDG uptake ratio between various metastatic lesions and primary tumour in patients with advanced serous epithelial ovarian cancer (EOC).
We retrospectively reviewed patients with International Federation of Gynecology and Obstetrics (FIGO) stage III, IV serous EOC who underwent preoperative [18F]FDG PET/CT scans. Clinico-pathological variables and PET/CT parameters such as maximum standardized uptake value of the ovarian cancer (SUVovary), pelvic or para-aortic LN (SUVLN), peritoneal (SUVperit) and distant extra-peritoneal (SUVdist) metastatic lesions, and the metastatic lesion-to-ovarian cancer standardized uptake value ratio were assessed.
Clinico-pathological data were retrospectively reviewed for 97 eligible patients. The median progression-free survival (PFS) was 18 months (range, 6–90 months) and 59 (60.8 %) patients experienced recurrence. In multivariate regression analysis, older age (p = 0.035, hazard ratio (HR) 1.032, 95 % CI 1.002–1.062), and high SUVperit/SUVovary (p = 0.046, HR 1.755, 95 % CI 1.011–3.047) were independent risk factors of recurrence. Patient group categorized by SUVperit/SUVovary showed significant difference in PFS (Log-Rank test, p = 0.001).
In patients with advanced serous EOC, preoperative SUVperit/SUVovary measured by [18F]FDG PET/CT provides significant incremental performance for prediction of recurrence.
• PET/CT data from advanced serous epithelial ovarian cancer patients were analysed.
• Prognostic value of SUV ratio between metastatic and primary tumour was investigated.
• SUV perit /SUV ovary provides incremental performance for prediction of recurrence.
KeywordsPET scan Peritoneum Metastasis Prognosis Ovarian cancer
Epithelial ovarian cancer
International Federation of Gynaecology and Obstetrics
Positron emission tomography
Standardized uptake value
Peritoneal metastatic lesion
Distant extra-peritoneal metastatic lesion
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI14C1072).
Compliance with ethical standards
The scientific guarantor of this publication is Gi Jeong Cheon.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Institutional Review Board approval was obtained.
Written informed consent was waived by the Institutional Review Board.
Study subjects or cohorts overlap
Data from 73 patients in a previous study were included in the current analysis . This study is different from previous one in that it performed lesion-specific analysis.
• diagnostic or prognostic study
• performed at one institution
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