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Feasibility of free-breathing dynamic contrast-enhanced MRI of gastric cancer using a golden-angle radial stack-of-stars VIBE sequence: comparison with the conventional contrast-enhanced breath-hold 3D VIBE sequence

  • Magnetic Resonance
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To investigate the feasibility and diagnostic value of free-breathing, radial, stack-of-stars three-dimensional (3D) gradient echo (GRE) sequence (“golden angle”) on dynamic contrast-enhanced (DCE) MRI of gastric cancer.

Methods

Forty-three gastric cancer patients were divided into cooperative and uncooperative groups. Respiratory fluctuation was observed using an abdominal respiratory gating sensor. Those who breath-held for more than 15 s were placed in the cooperative group and the remainder in the uncooperative group. The 3-T MRI scanning protocol included 3D GRE and conventional breath-hold VIBE (volume-interpolated breath-hold examination) sequences, comparing images quantitatively and qualitatively. DCE-MRI parameters from VIBE images of normal gastric wall and malignant lesions were compared.

Results

For uncooperative patients, 3D GRE scored higher qualitatively, and had higher SNRs (signal-to-noise ratios) and CNRs (contrast-to-noise ratios) than conventional VIBE quantitatively. Though 3D GRE images scored lower in qualitative parameters compared with conventional VIBE for cooperative patients, it provided images with fewer artefacts. DCE parameters differed significantly between normal gastric wall and lesions, with higher Ve (extracellular volume) and lower Kep (reflux constant) in gastric cancer.

Conclusions

The free-breathing, golden-angle, radial stack-of-stars 3D GRE technique is feasible for DCE-MRI of gastric cancer. Dynamic enhanced images can be used for quantitative analysis of this malignancy.

Key Points

• Golden-angle radial stack-of-stars VIBE aids gastric cancer MRI diagnosis.

• The 3D GRE technique is suitable for patients unable to suspend respiration.

• Method scored higher in the qualitative evaluation for uncooperative patients.

• The technique produced images with fewer artefacts than conventional VIBE sequence.

• Dynamic enhanced images can be used for quantitative analysis of gastric cancer.

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Abbreviations

AUC:

Area under the curve

BH:

Breath-hold

CNR:

Contrast-to-noise ratio

CT:

Computed tomography

DCE:

Dynamic contrast-enhanced

FB:

Free-breathing

GRE:

Gradient echo

Kep:

Extravascular-to-plasma volume transfer

Ktrans:

Plasma-to-extravascular volume transfer

MDCT:

Multiple-detector computed tomography

MRI:

Magnetic resonance imaging

ROI:

Region of interest

SD:

Standard deviation

SI:

Signal intensity

SNR:

Signal-to-noise ratio

Ve:

Extravascular fluid volume fraction

VIBE:

Volume-interpolated breath-hold examination

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Funding

This study has received funding by the innovation funds for development of science and technology in PuDong new area, Fund code: PKJ2013-Y07

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Author notes

  1. Huan-Huan Li and Hui Zhu contributed equally to this work and should be considered co-first authors

Authors and Affiliations

  1. Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China

    Huan-Huan Li, Hui Zhu, Lei Yue, Yi Fu & Wei-jun Peng

  2. Department of Radiology, Shanghai Pudong New Area Gongli Hospital, Shanghai, China

    Huan-Huan Li

  3. MR Applications Development, Siemens Healthcare, Erlangen, Germany

    Robert Grimm & Alto Stemmer

  4. MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

    Cai-Xia Fu

Authors
  1. Huan-Huan Li
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  2. Hui Zhu
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  5. Robert Grimm
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  8. Wei-jun Peng
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Corresponding author

Correspondence to Wei-jun Peng.

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Guarantor

The scientific guarantor of this publication is Wei-jun Peng.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was obtained from all patients in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

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• performed at one institution

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Li, HH., Zhu, H., Yue, L. et al. Feasibility of free-breathing dynamic contrast-enhanced MRI of gastric cancer using a golden-angle radial stack-of-stars VIBE sequence: comparison with the conventional contrast-enhanced breath-hold 3D VIBE sequence. Eur Radiol 28, 1891–1899 (2018). https://doi.org/10.1007/s00330-017-5193-1

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  • DOI: https://doi.org/10.1007/s00330-017-5193-1

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