Feasibility of free-breathing dynamic contrast-enhanced MRI of gastric cancer using a golden-angle radial stack-of-stars VIBE sequence: comparison with the conventional contrast-enhanced breath-hold 3D VIBE sequence
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To investigate the feasibility and diagnostic value of free-breathing, radial, stack-of-stars three-dimensional (3D) gradient echo (GRE) sequence (“golden angle”) on dynamic contrast-enhanced (DCE) MRI of gastric cancer.
Forty-three gastric cancer patients were divided into cooperative and uncooperative groups. Respiratory fluctuation was observed using an abdominal respiratory gating sensor. Those who breath-held for more than 15 s were placed in the cooperative group and the remainder in the uncooperative group. The 3-T MRI scanning protocol included 3D GRE and conventional breath-hold VIBE (volume-interpolated breath-hold examination) sequences, comparing images quantitatively and qualitatively. DCE-MRI parameters from VIBE images of normal gastric wall and malignant lesions were compared.
For uncooperative patients, 3D GRE scored higher qualitatively, and had higher SNRs (signal-to-noise ratios) and CNRs (contrast-to-noise ratios) than conventional VIBE quantitatively. Though 3D GRE images scored lower in qualitative parameters compared with conventional VIBE for cooperative patients, it provided images with fewer artefacts. DCE parameters differed significantly between normal gastric wall and lesions, with higher Ve (extracellular volume) and lower Kep (reflux constant) in gastric cancer.
The free-breathing, golden-angle, radial stack-of-stars 3D GRE technique is feasible for DCE-MRI of gastric cancer. Dynamic enhanced images can be used for quantitative analysis of this malignancy.
• Golden-angle radial stack-of-stars VIBE aids gastric cancer MRI diagnosis.
• The 3D GRE technique is suitable for patients unable to suspend respiration.
• Method scored higher in the qualitative evaluation for uncooperative patients.
• The technique produced images with fewer artefacts than conventional VIBE sequence.
• Dynamic enhanced images can be used for quantitative analysis of gastric cancer.
KeywordsStomach neoplasms Magnetic resonance imaging DCE Golden-angle radial VIBE Stack of stars
Area under the curve
Extravascular-to-plasma volume transfer
Plasma-to-extravascular volume transfer
Multiple-detector computed tomography
Magnetic resonance imaging
Region of interest
Extravascular fluid volume fraction
Volume-interpolated breath-hold examination
This study has received funding by the innovation funds for development of science and technology in PuDong new area, Fund code: PKJ2013-Y07
Compliance with ethical standards
The scientific guarantor of this publication is Wei-jun Peng.
Statistics and biometry
One of the authors has significant statistical expertise.
Written informed consent was obtained from all patients in this study.
Institutional Review Board approval was obtained.
• performed at one institution
- 3.Imaging Technology Branch and Radiology Branch of Chinese Medical Association (2016) Expert consensus about MRI examination technology. Chin J Radiol 50:724–739Google Scholar
- 23.Fujinaga Y, Ohya A, Tokoro H, Yamada A, Ueda K et al (2014) Radial volumetric imaging breath-hold examination (VIBE) with k-space weighted image contrast (KWIC) for dynamic gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI of the liver: advantages over Cartesian VIBE in the arterial phase. Eur Radiol 24:1290–1299CrossRefPubMedGoogle Scholar