European Radiology

, Volume 28, Issue 5, pp 1929–1937 | Cite as

18F-fluorodeoxyglucose specimen-positron emission mammography delineates tumour extension in breast-conserving surgery: Preliminary results

  • Gou Watanabe
  • M. Itoh
  • X. Duan
  • H. Watabe
  • N. Mori
  • H. Tada
  • A. Suzuki
  • M. Miyashita
  • N. Ohuchi
  • T. Ishida
Breast
  • 107 Downloads

Abstract

Objectives

We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (18F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff.

Methods

Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remaining 18F-FDG accumulation were scanned by high-resolution PEM. At least 1 day after surgery, tumour extension was evaluated by three independent experienced readers and by binarized images from the specimen-PEM data. Intraoperative exposure of medical staff to 18F-FDG was measured.

Results

Specimen-PEM evaluations of binarized images and the three investigators detected all (100 %, 12/12) invasive lesions and 94.4 % (17/18) of in situ lesions using both methods. The positive predictive value of the accumulated lesions was 74.4 % (29/39) for the binarized images and 82.9 % (29/35) for the three investigators. Analysis of intraoperative frozen sections detected 100 % (2/2) of the margin-positive cases, also detected by both specimen-PEM evaluation methods with no false-positive margin cases. The mean exposure of the medical staff to 18F was 18 μSv.

Conclusions

Specimen-PEM detected invasive and in situ lesions with high accuracy and allowable radiation exposure.

Key points

• Specimen-PEM detected invasive and in situ lesions with high accuracy.

• Specimen-PEM predicted complete resection with the same accuracy as frozen section analysis.

• Breast-conserving surgery after fluorodeoxyglucose injection was performed with low medical staff exposure.

Keywords

Fluorodeoxyglucose Positron emission mammography Breast-conserving surgery Surgical margin Frozen section analysis 

Notes

Acknowledgements

The authors thank Mika Watanabe, MD, PhD, and Saki Nakagawa, MD, PhD, of Tohoku University Hospital, Sendai, Japan, for their pathological work.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Prof. Takanori Ishida.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• diagnostic or prognostic study

• performed at one institution

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Copyright information

© European Society of Radiology 2017

Authors and Affiliations

  • Gou Watanabe
    • 1
  • M. Itoh
    • 2
  • X. Duan
    • 2
  • H. Watabe
    • 3
  • N. Mori
    • 4
  • H. Tada
    • 1
  • A. Suzuki
    • 5
  • M. Miyashita
    • 1
  • N. Ohuchi
    • 1
  • T. Ishida
    • 1
  1. 1.Division of Surgical OncologyTohoku University School of MedicineSendaiJapan
  2. 2.Sendai Medical Imaging CenterSendaiJapan
  3. 3.Cyclotron and Radioisotope CenterTohoku UniversitySendaiJapan
  4. 4.Division of Diagnostic RadiologyTohoku University School of MedicineSendaiJapan
  5. 5.Department of Breast and Endocrine SurgeryTohoku Medical and Pharmaceutical UniversitySendaiJapan

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