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Comparison of transient severe motion in gadoxetate disodium and gadopentetate dimeglumine-enhanced MRI: effect of modified breath-holding method

  • Magnetic Resonance
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To compare the occurrence of transient severe motion (TSM) between gadoxetate disodium- and gadopentetate dimeglumine-enhanced MRI and between gadoxetate disodium-enhanced MRI scans obtained with and without the application of a modified breath-holding technique.

Methods

We reviewed 80 patients who underwent two magnetic resonance examinations (gadoxetate disodium-enhanced MRI and gadopentetate dimeglumine-enhanced MRI) with the application of a modified breath-holding technique (dual group). This group was compared with 100 patients who underwent gadoxetate disodium-enhanced MRI without the application of the modified breath-holding technique (single group). Patient risk factors and motion scores (1 [none] to 5 [non-diagnostic]) for each dynamic-phase imaging were analysed.

Results

In the dual group, mean motion scores did not differ significantly between gadoxetate disodium- and gadopentetate dimeglumine-enhanced MRI (p=0.096–0.807) in any phase. However, in all phases except the late dynamic phase, mean motion scores of the dual group were significantly lower than those in the single group. TSM incidence did not differ significantly between gadoxetate disodium- and gadopentetate dimeglumine-enhanced MRI in the dual group (3.8% vs. 1.3%, p=0.620).

Conclusion

With proper application of the modified breath-holding technique, TSM occurrence with gadoxetate disodium-enhanced MRI was comparable to that associated with gadopentetate dimeglumine-enhanced MRI.

Key Points

• The modified breath-holding method significantly reduced the incidence of TSM.

• Gadoxetate disodium and gadopentetate dimeglumine showed comparable motion scores.

• TSM incidence was comparable between gadoxetate disodium- and gadopentetate dimeglumine-enhanced MRI.

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Abbreviations

TSM:

Transient severe motion

COPD:

Chronic obstructive pulmonary disease

MELD:

Model for End-stage Liver Disease

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Acknowledgments

The authors thank the MR radiographers of our unit, Mr. Hyun-Geun Lee, Mr. Chun-Ki Baek, and Mr. Eun-Seong Kim, for technical assistance with MR studies.

Funding

This research was supported by the Research Base Construction Fund Support Program funded by Chonbuk National University in 2017.

Author information

Authors and Affiliations

  1. Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea

    Ji Soo Song, Eun Jung Choi & Eun Hae Park

  2. Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, Korea

    Ji Soo Song, Eun Jung Choi & Eun Hae Park

  3. Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea

    Ji Soo Song, Eun Jung Choi & Eun Hae Park

  4. Department of Preventive Medicine, Chonbuk National University Medical School, Jeonju, Korea

    Ju-Hyung Lee

Authors
  1. Ji Soo Song
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  2. Eun Jung Choi
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Corresponding author

Correspondence to Ji Soo Song.

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Guarantor

The scientific guarantor of this publication is Ji Soo Song.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

Statistical analysis was performed by Dr. Ju-Hyung Lee, who is an expert in statistics.

Ethical approval

Institutional Review Board approval was obtained.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Study subjects or cohorts overlap

Data from the 35 patients were published previously (Kim et al. Invest Radiol 2010;45:740–746). These patients were prospectively enrolled to compare the diagnostic accuracy and sensitivity of Gd-EOB-MRI with double-contrast MRI, which combined Gd-DTPA-MRI and superparamagnetic iron oxide-enhanced MRI, for HCC detection. In this study, we only used the dynamic-phase images of patients who underwent both gadoxetate disodium- and gadopentetate dimeglumine-enhanced MRI in order to compare the incidence of TSM.

Methodology

• retrospective

• observational

• performed at one institution

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Song, J.S., Choi, E.J., Park, E.H. et al. Comparison of transient severe motion in gadoxetate disodium and gadopentetate dimeglumine-enhanced MRI: effect of modified breath-holding method. Eur Radiol 28, 1132–1139 (2018). https://doi.org/10.1007/s00330-017-5070-y

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  • DOI: https://doi.org/10.1007/s00330-017-5070-y

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