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Myocardial iodine concentration measurement using dual-energy computed tomography for the diagnosis of cardiac amyloidosis: a pilot study

  • Cardiac
  • Published:
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Abstract

Objective

To measure myocardium iodine concentration (MIC) in patients with cardiac amyloidosis (CA) using dual-energy computed tomography (DECT).

Methods

Twenty-two patients with CA, 13 with non-amyloid hypertrophic cardiomyopathies (CH) and 10 control patients were explored with pre-contrast, arterial and 5-minute DECT acquisition (Iomeprol; 1.5 mL/kg). Inter-ventricular septum (IVS) thickness, blood pool iodine concentration (BPIC), MIC (mg/mL), iodine ratio and extra-cellular volume (ECV) were calculated.

Results

IVS thickness was significantly (p < 0.001) higher in CA (17 ± 4 mm) and CH (15 ± 3 mm) patients than in control patients (10 ± 1 mm). CA patients exhibited significantly (p < 0.001) higher 5-minute MIC [2.6 (2.3–3.1) mg/mL], 5-minute iodine ratio (0.88 ± 0.12) and ECV (0.56 ± 0.07) than CH [1.7 (1.4–2.2) mg/mL, 0.57 ± 0.07 and 0.36 ± 0.05, respectively] and control patients [1.9 (1.7–2.4) mg/mL, 0.58 ± 0.07 and 0.35 ± 0.04, respectively). CH and control patients exhibited similar values (p = 0.9). The area under the curve of 5-minute iodine ratio for the differential diagnosis of CA from CH patients was 0.99 (0.73–1.0; p = 0.001). With a threshold of 0.65, the sensitivity and specificity of 5-minute iodine ratio were 100% and 92%, respectively.

Conclusion

Five-minute MIC and iodine ratio were increased in CA patients and exhibited best diagnosis performance to diagnose CA in comparison to other parameters.

Key point

• Dual-energy computed tomography can be used to detect cardiac amyloidosis

• Five-minute myocardial iodine concentration and iodine ratio increase in cardiac amyloidosis

• Among iodine parameters, 5-minute iodine ratio has the best diagnosis performance

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Abbreviations

BPIC:

Blood pool iodine concentration

CA:

Cardiac amyloidosis

CH:

Cardiac hypertrophy

DECT:

Dual-energy computed tomography

EMB:

Endo-myocardial biopsy

ECV:

Extra-cellular volume

GSI:

Gemstone spectral imaging

HCM:

Hypertrophic cardiomyopathy

IVS:

Inter-ventricular septum

AL:

Light-chain amyloidosis

MIC:

Myocardium iodine concentration

ATTR:

Transthyretin amyloidosis

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Authors and Affiliations

  1. Service d’Imagerie Médicale, AP-HP (Assistance Publique–Hôpitaux de Paris, Créteil), Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, F-94000, France

    Virgile Chevance, Vania Tacher, François Legou, Fourat Ridouani, Alain Luciani, Hicham Kobeiter, Alain Rahmouni & Jean-François Deux

  2. Service de Cardiologie, AP-HP (Assistance Publique–Hôpitaux de Paris, Créteil), Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, F-94000, France

    Thibaud Damy

  3. DHU (Département Hospitalo-Universitaire) ATVB (Ageing-Thorax-Vessels-Blood), IMRB (Institut Mondor de Recherche Biomédicale), Université Paris-Est-Créteil, (UPEC), Créteil, F-94000, France

    Thibaud Damy, Vania Tacher, Hicham Kobeiter & Jean-François Deux

  4. GRC Amyloid Research Institute and Reseau Amylose Mondor, Groupe Hospitalier Henri Mondor-Albert Chenevier, Université Paris-Est-Créteil (UPEC), Créteil, F-94000, France

    Thibaud Damy & Jean-François Deux

  5. DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunity-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Université Paris-Est-Créteil, (UPEC), Créteil, F-94000, France

    Alain Luciani & Alain Rahmouni

Authors
  1. Virgile Chevance
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  2. Thibaud Damy
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  3. Vania Tacher
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  4. François Legou
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  9. Jean-François Deux
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Corresponding author

Correspondence to Virgile Chevance.

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Guarantor

The scientific guarantor of this publication is Jean-François Deux.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Funding

The authors state that this work has not received any funding.

Statistics and biometry

One of the authors has significant statistical expertise.

Ethical approval

Institutional review board approval was obtained.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Methodology

• prospective

• experimental

• performed at one institution

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Chevance, V., Damy, T., Tacher, V. et al. Myocardial iodine concentration measurement using dual-energy computed tomography for the diagnosis of cardiac amyloidosis: a pilot study. Eur Radiol 28, 816–823 (2018). https://doi.org/10.1007/s00330-017-4984-8

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  • DOI: https://doi.org/10.1007/s00330-017-4984-8

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